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Literature summary extracted from
- Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzyme a cycle enzymes in liver (1975), J. Biol. Chem., 250, 3108-3116.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.1.3.4 | mitochondrion | matrix | Gallus gallus | 5739 | - |
| 4.1.3.4 | mitochondrion | matrix | Rattus norvegicus | 5739 | - |
| 4.1.3.4 | mitochondrion | exclusively | Gallus gallus | 5739 | - |
| 4.1.3.4 | mitochondrion | exclusively | Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA | Gallus gallus | involved in ketogenesis, leucine catabolism | ? | - |
? |  |
| 4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA | Rattus norvegicus | involved in ketogenesis, leucine catabolism | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.3.4 | Gallus gallus | - |
chicken | - |
| 4.1.3.4 | Rattus norvegicus | - |
rat | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.3.4 | brain | - |
Gallus gallus | - |
| 4.1.3.4 | heart | - |
Gallus gallus | - |
| 4.1.3.4 | ileum | low activity | Gallus gallus | - |
| 4.1.3.4 | kidney | - |
Gallus gallus | - |
| 4.1.3.4 | liver | - |
Gallus gallus | - |
| 4.1.3.4 | liver | - |
Rattus norvegicus | - |
| 4.1.3.4 | muscle | low activity | Gallus gallus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.3.4 | additional information | - |
organ-specific activities per unit freshweight | Gallus gallus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA | involved in ketogenesis, leucine catabolism | Gallus gallus | ? | - |
? | |
| 4.1.3.4 | (S)-3-Hydroxy-3-methylglutaryl-CoA | involved in ketogenesis, leucine catabolism | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.1.3.4 | 30 | - |
enzyme assay at | Gallus gallus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.3.4 | 8.4 | - |
enzyme assay at | Gallus gallus |
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Release 2023.1 (January 2023)
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