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Literature summary extracted from

  • Pirzer, P.; Lill, U.; Eggerer, H.
    Nicotinic acid metabolism. 2,3-Dimethylmalate lyase (1979), Hoppe-Seyler's Z. Physiol. Chem., 360, 1693-1702.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.3.32 mercaptans activity is dependent on Eubacterium barkeri

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.32 cystamine
-
 Eubacterium barkeri
4.1.3.32 Disulfide
-
 Eubacterium barkeri
4.1.3.32 iodoacetamide
-
 Eubacterium barkeri
4.1.3.32 iodoacetate
-
 Eubacterium barkeri
4.1.3.32 Mg2+ above 10 mM; inhibits at high concentrations Eubacterium barkeri

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.3.32 0.66
-
 2,3-dimethylmalate
-
 Eubacterium barkeri

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.3.32 Mg2+ Km: 0.14 mM Eubacterium barkeri
4.1.3.32 Mg2+ inhibitory above 10 mM Eubacterium barkeri

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.3.32 125000
-
 gel filtration Eubacterium barkeri

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.32 Eubacterium barkeri
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.32
-
 Eubacterium barkeri

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.32 2,3-Dimethylmalate
-
 Eubacterium barkeri Propanoate + pyruvate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.3.32 8
-
-
 Eubacterium barkeri