Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shamu, C.E.; Walter, P.
    Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus (1996), EMBO J., 15, 3028-3039.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 cytoplasm Ire1p spans the ER membrane or the nuclear membrane with which the ER is continuous, with its kinase domain localized in the cytoplasm or in the nucleus Saccharomyces cerevisiae 5737
-
2.7.11.1 membrane a transmembrane enzyme Saccharomyces cerevisiae 16020
-
2.7.11.1 membrane Ire1p spans the ER membrane or the nuclear membrane with which the ER is continuous, with its kinase domain localized in the cytoplasm or in the nucleus Saccharomyces cerevisiae 16020
-
2.7.11.1 nucleus Ire1p spans the ER membrane or the nuclear membrane with which the ER is continuous, with its kinase domain localized in the cytoplasm or in the nucleus Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + a protein Saccharomyces cerevisiae Ire1p is required for activation of the unfolded protein response. It senses the accumulation of unfolded proteins in the ER and transmits the signal across the membrane toward the transcription machinery, possibly by phosphorylating downstream components of the UPR pathway ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Saccharomyces cerevisiae P32361
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein Ire1p oligomerizes in response to the accumulation of unfolded proteins in the ER and is phosphorylated in trans by other Ire1p molecules as a result of oligomerization Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + a protein Ire1p is required for activation of the unfolded protein response. It senses the accumulation of unfolded proteins in the ER and transmits the signal across the membrane toward the transcription machinery, possibly by phosphorylating downstream components of the UPR pathway Saccharomyces cerevisiae ADP + a phosphoprotein
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.1 More Ire1p oligomerizes in response to the accumulation of unfolded proteins in the ER Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 Ire1p kinase
-
 Saccharomyces cerevisiae
2.7.11.1 serine/threonine-protein kinase IRE1 precursor
-
 Saccharomyces cerevisiae