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Literature summary extracted from

  • Udo, H.; Munoz-Dorado, J.; Inouye, M.; Inouye, S.
    Myxococcus xanthus, a gram-negative bacterium, contains a transmembrane protein serine/threonine kinase that blocks the secretion of beta-lactamase by phosphorylation (1995), Genes Dev., 9, 972-983.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 expression in Escherichia coli under a T7 promoter Myxococcus xanthus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 membrane Pkn2 is a transmembrane protein with the kinase domain in the cytoplasm and the 207-residue carboxy-terminal domain outside the cytoplasmic membrane Myxococcus xanthus 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + a protein Myxococcus xanthus the enzyme blocks the secretion of beta-lactamase by phosphorylation ADP + a phosphoprotein
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Myxococcus xanthus P54736
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein phosphorylated at both Ser and Thr residues Myxococcus xanthus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + a protein the enzyme blocks the secretion of beta-lactamase by phosphorylation Myxococcus xanthus ADP + a phosphoprotein
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 ?
2.7.11.1 ATP + TEM-beta-lactamase the enzyme is phosphorylated only at Thr residues, shifting its apparent molecular mass from 29000 Da to 44000 Da. The phosphorylated beta-lactamase is unable to be secreted into the periplasmic space and localized in the cytoplasmic and membrane fractions Myxococcus xanthus ADP + phosphorylated TEM-beta-lactamase
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 serine/threonine-protein kinase pkn2
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 Myxococcus xanthus