Literature summary extracted from

Regnier, C.H.; Song, H.Y.; Gao, X.; Goeddel, D.V.; Cao, Z.; Rothe, M.
Identification and characterization of an IkappaB kinase (1997), Cell, 90, 373-383.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.11.10	ATP + a protein	Homo sapiens	CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway	ADP + a phosphoprotein	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.11.10	Homo sapiens	O15111	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.11.10	ATP + a protein	CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway	Homo sapiens	ADP + a phosphoprotein	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.11.10	inhibitor of nuclear factor kappa B kinase beta subunit inhibitor of nuclear factor kappa-B kinase alpha subunit	-	Homo sapiens

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Release 2023.1 (January 2023)