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Literature summary extracted from

  • Delhase, M.; Hayakawa, M.; Chen, Y.; Karin, M.
    Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation (1999), Science, 284, 309-313.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + a protein Homo sapiens phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses ADP + a phosphoprotein
-
 ?
2.7.11.10 ATP + a protein Mus musculus phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens O15111
-
-
2.7.11.10 Mus musculus Q60680
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + a protein phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses Homo sapiens ADP + a phosphoprotein
-
 ?
2.7.11.10 ATP + a protein phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses Mus musculus ADP + a phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaBalpha
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 Homo sapiens
2.7.11.10 inhibitor of nuclear factor kappa B kinase beta subunit inhibitor of nuclear factor kappa-B kinase alpha subunit
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 Homo sapiens
2.7.11.10 inhibitor of nuclear factor kappa-B kinase alpha subunit
-
 Mus musculus