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Literature summary extracted from

  • Kentrup, H.; Becker, W.; Heukelbach, J.; Wilmes, A.; Schurmann, A.; Huppertz, C.; Kainulainen, H.; Joost, H.G.
    Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII (1996), J. Biol. Chem., 271, 3488-3495.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.1
-
Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.12.1 additional information exchange of two Tyr residues in the activation loop between subdomains VII and VIII for Phe almost completely suppresses the activity and Tyr autophosphorylation of Dyrk. Tyr autophosphorylation is also reduced by exchange of Tyr219 in a tyrosine phosphorylation consensus motif Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.1 ATP + SR protein Rattus norvegicus might be a component of a signaling pathway regulating nuclear functions ADP + ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.1 Rattus norvegicus Q63470
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.12.1 phosphoprotein autophosphorylation Rattus norvegicus
2.7.12.1 phosphoprotein dual specificity protein kinase that is regulated by tyrosine phosphorylation in the activation loop Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.1 brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.1 ATP + histone recombinant glutathione S-transferase-Dyrk/fusion protein catalyzes histone phosphorylation on tyrosine and Ser/Thr residues Rattus norvegicus ADP + phosphorylated histone
-
?
2.7.12.1 ATP + protein autophosphorylation Rattus norvegicus ADP + phosphoprotein
-
?
2.7.12.1 ATP + SR protein might be a component of a signaling pathway regulating nuclear functions Rattus norvegicus ADP + ?
-
?
2.7.12.1 additional information activity is dependent on tyrosine residues between subdomains VII and VIII Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.1 dual-specificity tyrosine-phosphorylation regulated kinase 1A
-
Rattus norvegicus
2.7.12.1 DYRK
-
Rattus norvegicus