EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.12.1 | - |
Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.12.1 | additional information | exchange of two Tyr residues in the activation loop between subdomains VII and VIII for Phe almost completely suppresses the activity and Tyr autophosphorylation of Dyrk. Tyr autophosphorylation is also reduced by exchange of Tyr219 in a tyrosine phosphorylation consensus motif | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.12.1 | ATP + SR protein | Rattus norvegicus | might be a component of a signaling pathway regulating nuclear functions | ADP + ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.12.1 | Rattus norvegicus | Q63470 | - |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.12.1 | phosphoprotein | autophosphorylation | Rattus norvegicus |
2.7.12.1 | phosphoprotein | dual specificity protein kinase that is regulated by tyrosine phosphorylation in the activation loop | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.12.1 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.12.1 | ATP + histone | recombinant glutathione S-transferase-Dyrk/fusion protein catalyzes histone phosphorylation on tyrosine and Ser/Thr residues | Rattus norvegicus | ADP + phosphorylated histone | - |
? | |
2.7.12.1 | ATP + protein | autophosphorylation | Rattus norvegicus | ADP + phosphoprotein | - |
? | |
2.7.12.1 | ATP + SR protein | might be a component of a signaling pathway regulating nuclear functions | Rattus norvegicus | ADP + ? | - |
? | |
2.7.12.1 | additional information | activity is dependent on tyrosine residues between subdomains VII and VIII | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.12.1 | dual-specificity tyrosine-phosphorylation regulated kinase 1A | - |
Rattus norvegicus |
2.7.12.1 | DYRK | - |
Rattus norvegicus |