BRENDA - Enzyme Database show

Homology modelling of the enzyme P450 17alpha-hydroxylase/17,20-lyase-a taget for prostate cancer chemotherapy-from the crystal structure of P450BM-3

Burke, D.F.; Laughton, C.A.; Neidle, S.; Anticancer Drug Des. 12, 113-123 (1997)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
1.14.14.32
medicine
homology modelling of the enzyme cytochrome P450 17alpha-hydroxylase/17,20-lyase (P450c17)-a target for prostate cancer chemotherapy-from the crystal structure of P450BM-3
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.32
ketoconazole
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.14.32
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.32
17alpha-Hydroxypregnenolone
-
5131
Homo sapiens
Dehydroepiandrosterone + acetaldehyde
DHEA
5131
Homo sapiens
-
1.14.14.32
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
5131
Homo sapiens
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
androstenedione
5131
Homo sapiens
-
Application (protein specific)
EC Number
Application
Commentary
Organism
1.14.14.32
medicine
homology modelling of the enzyme cytochrome P450 17alpha-hydroxylase/17,20-lyase (P450c17)-a target for prostate cancer chemotherapy-from the crystal structure of P450BM-3
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.32
ketoconazole
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.32
17alpha-Hydroxypregnenolone
-
5131
Homo sapiens
Dehydroepiandrosterone + acetaldehyde
DHEA
5131
Homo sapiens
-
1.14.14.32
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
5131
Homo sapiens
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
androstenedione
5131
Homo sapiens
-