BRENDA - Enzyme Database show

Inhibition of steroid C17(20) lyase with C-17-heteroaryl steroids

Burkhart, J.P.; Gates, C.A.; Laughlin, M.E.; Resvick, R.J.; Peet, N.P.; Bioorg. Med. Chem. 4, 1411-1420 (1996)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
1.14.14.32
medicine
inhibition of EC 4.1.2.30 is a potential therapeutic approach for the treatment of both breast and prostrate cancers
Macaca fascicularis
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.32
additional information
overview
Macaca fascicularis
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.14.32
Macaca fascicularis
-
cynomolgus monkey
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.32
testis
-
Macaca fascicularis
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.32
17alpha-Hydroxypregnenolone
-
5130
Macaca fascicularis
Dehydroepiandrosterone + acetaldehyde
DHEA
5130
Macaca fascicularis
-
1.14.14.32
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
5130
Macaca fascicularis
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
5130
Macaca fascicularis
-
Application (protein specific)
EC Number
Application
Commentary
Organism
1.14.14.32
medicine
inhibition of EC 4.1.2.30 is a potential therapeutic approach for the treatment of both breast and prostrate cancers
Macaca fascicularis
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.32
additional information
overview
Macaca fascicularis
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.32
testis
-
Macaca fascicularis
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.32
17alpha-Hydroxypregnenolone
-
5130
Macaca fascicularis
Dehydroepiandrosterone + acetaldehyde
DHEA
5130
Macaca fascicularis
-
1.14.14.32
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
5130
Macaca fascicularis
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
5130
Macaca fascicularis
-