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Literature summary extracted from

  • Machinist, J.M.; Orme-Johnson, W.H.; Ziegler, D.M.
    Microsomal oxidases. II. Properties of a pork liver microsomal N-oxide dealkylase (1966), Biochemistry, 5, 2939-2943.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.24 alpha-Phenyl-alpha-propyl-benzeneacetic acid 2-(diethylamino) ethyl ester SKF-525A Sus scrofa
4.1.2.24 CO
-
Sus scrofa
4.1.2.24 Pyridine
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.2.24 6
-
N,N-dimethylnaphthylamine N-oxide
-
Sus scrofa
4.1.2.24 7
-
N,N-dimethylnaphthylamine N-oxide in presence of N,N-dimethylcyclohexylamine Sus scrofa
4.1.2.24 15
-
N,N-Dimethyl-p-toluidine N-oxide
-
Sus scrofa
4.1.2.24 20
-
N,N-Dimethyl-p-toluidine N-oxide in presence of N,N-dimethylcyclohexylamine Sus scrofa
4.1.2.24 33
-
N,N-Dimethylaniline N-oxide
-
Sus scrofa
4.1.2.24 80
-
N,N-Dimethylaniline N-oxide in presence of N,N-dimethylcyclohexylamine Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.2.24 microsome
-
Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.24 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.2.24 liver
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.24 additional information no activity with N-oxide derivatives of trialkylamines, morphine N-ethyl derivatives of aniline N-oxide are dealkylated at a slower rate than methyl derivatives Sus scrofa ?
-
?
4.1.2.24 N,N-Dimethyl-p-toluidine N-oxide
-
Sus scrofa ?
-
?
4.1.2.24 N,N-Dimethyl1-naphthylamine N-oxide
-
Sus scrofa N-Methylaniline + formaldehyde
-
?
4.1.2.24 N,N-Dimethylaniline N-oxide
-
Sus scrofa ?
-
?
4.1.2.24 N-Ethyl-N-methylaniline N-oxide weak activity Sus scrofa ?
-
?
4.1.2.24 p-Chlorodimethylaniline N-oxide
-
Sus scrofa ?
-
?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.24 Microsomal oxidase II
-
Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.2.24 6.8 7
-
Sus scrofa