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Literature summary extracted from

  • Bais, R.; James, H.M.; Rofe, A.M.; Conyers, A.J.
    The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol (1985), Biochem. J., 230, 53-60.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.3 N-ethylmaleimide
-
 Homo sapiens
2.7.1.3 PCMB
-
 Homo sapiens
4.1.2.13 ADP
-
 Homo sapiens
4.1.2.13 ascorbic acid
-
 Homo sapiens
4.1.2.13 ATP
-
 Homo sapiens
4.1.2.13 erythrose 4-phosphate
-
 Homo sapiens
4.1.2.13 fructose 6-phosphate
-
 Homo sapiens
4.1.2.13 glucose 1-phosphate
-
 Homo sapiens
4.1.2.13 glucose 6-phosphate
-
 Homo sapiens
4.1.2.13 Glycerol 2,3-diphosphate
-
 Homo sapiens
4.1.2.13 glyoxylate
-
 Homo sapiens
4.1.2.13 IMP
-
 Homo sapiens
4.1.2.13 ribose 5-phosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.3 0.86
-
 D-fructose 37°C, pH 7.5 Homo sapiens
2.7.1.3 6
-
 D-xylulose 37°C, pH 7.5 Homo sapiens
4.1.2.13 0.0016
-
 D-Xylulose 1-phosphate
-
 Homo sapiens
4.1.2.13 0.0037
-
 D-fructose 1,6-bisphosphate
-
 Homo sapiens
4.1.2.13 2
-
 fructose 1-phosphate
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.3 39000
-
 2 * 39000, SDS-PAGE Homo sapiens
2.7.1.3 75000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.3 ATP + D-fructose Homo sapiens role in formation of glycoaldehyde ADP + D-fructose 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.3 Homo sapiens
-
-
-
4.1.2.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.3
-
 Homo sapiens
4.1.2.13 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.3 brain
-
 Homo sapiens
-
2.7.1.3 heart
-
 Homo sapiens
-
2.7.1.3 kidney
-
 Homo sapiens
-
2.7.1.3 liver
-
 Homo sapiens
-
2.7.1.3 muscle
-
 Homo sapiens
-
4.1.2.13 brain
-
 Homo sapiens
-
4.1.2.13 heart
-
 Homo sapiens
-
4.1.2.13 kidney
-
 Homo sapiens
-
4.1.2.13 liver
-
 Homo sapiens
-
4.1.2.13 muscle
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.3 9.4
-
-
 Homo sapiens
4.1.2.13 additional information
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.7.1.3 -20°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.3 ATP + D-fructose
-
 Homo sapiens ADP + D-fructose 1-phosphate
-
 ?
2.7.1.3 ATP + D-fructose role in formation of glycoaldehyde Homo sapiens ADP + D-fructose 1-phosphate
-
 ?
2.7.1.3 ATP + D-xylulose
-
 Homo sapiens ?
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate
-
 Homo sapiens glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.1.2.13 D-Fructose 1-phosphate 99% of the activity with fructose 1,6-diphosphate Homo sapiens Glycerone phosphate + D-glyceraldehyde
-
 ?
4.1.2.13 D-Xylulose 1-phosphate 110% of the activity with fructose 1,6-diphosphate Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.3 dimer 2 * 39000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.3 37
-
 assay at Homo sapiens