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Literature summary extracted from

  • Ullan, R.V.; Casqueiro, J.; Banuelos, O.; Fernandez, F.J.; Gutierrez, S.; Martin, J.F.
    A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum (2002), J. Biol. Chem., 277, 46216-46225.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Acremonium chrysogenum involved in biosynthesis of cephalosporin C isopenicillin N + 2 H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Acremonium chrysogenum C10 / ATCC 48272 involved in biosynthesis of cephalosporin C isopenicillin N + 2 H2O
-
 ?
5.1.1.17 isopenicillin N Amycolatopsis lactamdurans part of the cephalosporin pathway penicillin N
-
 ?
5.1.1.17 isopenicillin N Acremonium chrysogenum part of the cephalosporin pathway penicillin N
-
 ?
5.1.1.17 isopenicillin N Acremonium chrysogenum C10 / ATCC 48272 part of the cephalosporin pathway penicillin N
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.1 Acremonium chrysogenum
-
-
-
1.21.3.1 Acremonium chrysogenum C10 / ATCC 48272
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-
-
5.1.1.17 Acremonium chrysogenum
-
-
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5.1.1.17 Amycolatopsis lactamdurans
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 also known as Amycolatopsis lactamdurans, cefD1 and cefD2 gene products are involved in epimerization of isopenicillin N into penicillin N
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.1.1.17 additional information
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 92.0 units, 1 unit is the activity forming 1 ng of cephalosporin/min in a coupled assay, activity in cell extract Acremonium chrysogenum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Acremonium chrysogenum isopenicillin N + 2 H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 involved in biosynthesis of cephalosporin C Acremonium chrysogenum isopenicillin N + 2 H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Acremonium chrysogenum C10 / ATCC 48272 isopenicillin N + 2 H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 involved in biosynthesis of cephalosporin C Acremonium chrysogenum C10 / ATCC 48272 isopenicillin N + 2 H2O
-
 ?
5.1.1.17 isopenicillin
-
 Amycolatopsis lactamdurans penicillin N
-
 ?
5.1.1.17 isopenicillin
-
 Acremonium chrysogenum penicillin N
-
 ?
5.1.1.17 isopenicillin
-
 Acremonium chrysogenum C10 / ATCC 48272 penicillin N
-
 ?
5.1.1.17 isopenicillin N part of the cephalosporin pathway Amycolatopsis lactamdurans penicillin N
-
 ?
5.1.1.17 isopenicillin N part of the cephalosporin pathway Acremonium chrysogenum penicillin N
-
 ?
5.1.1.17 isopenicillin N part of the cephalosporin pathway Acremonium chrysogenum C10 / ATCC 48272 penicillin N
-
 ?