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Literature summary extracted from

  • Liu, H.; Sugiura, M.; Nava, V.E.; Edsall, L.C.; Kono, K.; Poulton, S.; Milstien, S.; Kohama, T.; Spiegel, S.
    Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform (2000), J. Biol. Chem., 275, 19513-19520.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.91
-
 Homo sapiens
2.7.1.91
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 KCl IC50 200 mM Mus musculus
2.7.1.91 N,N-dimethylsphingosine
-
 Homo sapiens
2.7.1.91 N,N-dimethylsphingosine
-
 Mus musculus
2.7.1.91 NaCl IC50 200 mM Mus musculus
2.7.1.91 Triton X-100 above 0.005% Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.91 0.0034
-
 D-(+)-erythro-sphinganine
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens Q9NRA0 SPHK2
-
2.7.1.91 Mus musculus Q9JIA7 SPHK2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 additional information tissue distribution Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + D-(+)-erythro-sphinganine
-
 Mus musculus ADP + D-(+)-erythro-sphinganine 1-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.91 7.5
-
-
 Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.91 6.5 8
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.91 0.012
-
 N,N-dimethylsphingosine
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.91 200
-
 IC50 200 mM Mus musculus NaCl
2.7.1.91 200
-
 IC50 200 mM Mus musculus KCl