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Literature summary extracted from

  • Stoffel, W.; Hellenbroich, B.; Heimann, G.
    Properties and specificities of sphingosine kinase from blood platelets (1973), Hoppe-Seyler's Z. Physiol. Chem., 354, 1311-1316.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 D(+)threo-Sphinganine
-
 Homo sapiens
2.7.1.91 EDTA
-
 Homo sapiens
2.7.1.91 L(-)erythro-Sphinganine
-
 Homo sapiens
2.7.1.91 L(-)threo-Sphinganine
-
 Homo sapiens
2.7.1.91 N-ethylmaleimide
-
 Homo sapiens
2.7.1.91 p-chloromercuribenzoate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.91 0.072
-
 D-(+)-erythro-sphinganine
-
 Homo sapiens
2.7.1.91 1
-
 L-(-)-threo-sphinganine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.91 cytoplasm
-
 Homo sapiens 5737
-
2.7.1.91 cytoplasm
-
 Sus scrofa 5737
-
2.7.1.91 soluble
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.91 Mg2+ stimulation at concentration equimolar to ATP Homo sapiens
2.7.1.91 Mn2+ stimulation at concentration equimolar to ATP Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens
-
-
-
2.7.1.91 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 thrombocyte
-
 Homo sapiens
-
2.7.1.91 thrombocyte
-
 Sus scrofa
-

Storage Stability

EC Number Storage Stability Organism
2.7.1.91 -18°C, stable for at least 3 weeks Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + D-(+)-erythro-sphinganine
-
 Homo sapiens ADP + D-(+)-erythro-sphinganine 1-phosphate
-
 ?
2.7.1.91 ATP + L-(-)-threo-sphinganine
-
 Homo sapiens ADP + L-(-)-threo-sphinganine 1-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.91 7
-
-
 Homo sapiens
2.7.1.91 7
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.91 6 8.5 pH 6: about 55% of maximum activity, pH 8.5: about 40% of maximum activity Homo sapiens