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Literature summary extracted from

  • Mott, H.R.; Carpenter, J.W.; Zhong, S.; Ghosh, S.; Bell, R.M.; Campbell, S.L.
    The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site (1996), Proc. Natl. Acad. Sci. USA, 93, 8312-8317.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a protein Homo sapiens the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals ADP + a phosphoprotein
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens P04049
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a protein the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 RAF proto-oncogene serine/threonine-protein kinase
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 Homo sapiens
2.7.10.2 Raf-1 protein kinase
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 Homo sapiens