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Literature summary extracted from

  • Toshima, J.; Toshima, J.Y.; Takeuchi, K.; Mori, R.; Mizuno, K.
    Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells (2001), J. Biol. Chem., 276, 31449-31458.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 additional information mutant lacking the C-terminal noncatalytic region has about a 10fold higher kinase activity in vitro and, when expressed in HeLa cells, induces punctate actin aggregates in the cytoplasm and unusual condensation and fragmentation of nuclei, followed by apoptosis Rattus norvegicus
2.7.10.2 additional information mutant lacking the C-terminal noncatalytic region has about a 10fold higher kinase activity in vitro and, when expressed in HeLa cells, induces punctate actin aggregates in the cytoplasm and unusual condensation and fragmentation of nuclei, followed by apoptosis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 nucleus localized mainly in Rattus norvegicus 5634
-
2.7.10.2 nucleus localized mainly in Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a protein Rattus norvegicus the enzyme induces formation of actin stress fibers and focal adhesions ADP + a phosphoprotein
-
 ?
2.7.10.2 ATP + a protein Homo sapiens the enzyme induces formation of actin stress fibers and focal adhesions ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens Q96S53
-
-
2.7.10.2 Rattus norvegicus Q924U5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 Sertoli cell predominant expression in Rattus norvegicus
-
2.7.10.2 Sertoli cell predominant expression in Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a protein the enzyme induces formation of actin stress fibers and focal adhesions Rattus norvegicus ADP + a phosphoprotein
-
 ?
2.7.10.2 ATP + a protein the enzyme induces formation of actin stress fibers and focal adhesions Homo sapiens ADP + a phosphoprotein
-
 ?
2.7.10.2 ATP + cofilin phosphorylation specifically at Ser-3 Rattus norvegicus ADP + phosphorylated cofilin
-
 ?
2.7.10.2 ATP + cofilin phosphorylation specifically at Ser-3 Homo sapiens ADP + phosphorylated cofilin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 TESK2
-
 Rattus norvegicus
2.7.10.2 TESK2
-
 Homo sapiens
2.7.10.2 testis-specific protein kinase 2
-
 Rattus norvegicus
2.7.10.2 testis-specific protein kinase 2
-
 Homo sapiens