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Literature summary extracted from

  • Wang, X.S.; Diener, K.; Jannuzzi, D.; Trollinger, D.; Tan, T.H.; Lichenstein, H.; Zukowski, M.; Yao, Z.
    Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase (1996), J. Biol. Chem., 271, 31607-31611.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.2 expression in COS and 293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Homo sapiens MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway ADP + phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Homo sapiens Q99683
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.2 macrophage
-
 Homo sapiens
-
2.7.12.2 pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + MKK4
-
 Homo sapiens ADP + phosphorylated MKK4
-
 ?
2.7.12.2 ATP + protein MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway Homo sapiens ADP + phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 mitogen-activated protein kinase kinase kinase 5
-
 Homo sapiens