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Literature summary extracted from

  • Ichijo, H.; Nishida, E.; Irie, K.; ten Dijke, P.; Saitoh, M.; Moriguchi, T.; Takagi, M.; Matsumoto, K.; Miyazono, K.; Gotoh, Y.
    Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways (1997), Science, 275, 90-94.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.12.2 additional information the enzyme is activated in cells treated with tumor necrosis factor-alpha Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Homo sapiens ASK1 may be a key element in the mechanism of stress-induced and cytokine-induced apoptosis ADP + phosphoprotein
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Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Homo sapiens Q99683
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.2 heart
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + protein ASK1 may be a key element in the mechanism of stress-induced and cytokine-induced apoptosis Homo sapiens ADP + phosphoprotein
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 ASK1
-
Homo sapiens
2.7.12.2 MAPKKK5
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Homo sapiens
2.7.12.2 mitogen-activated protein kinase kinase kinase 5
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Homo sapiens