EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.12.2 | ATP + protein | Homo sapiens | MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2. The enzyme is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins, additional role for MKK4 in tumor suppression | ADP + phosphoprotein | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.12.2 | Homo sapiens | P45985 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.12.2 | breast cancer cell line | - |
Homo sapiens | - |
2.7.12.2 | colonic cancer cell line | colorectal cancer cell line | Homo sapiens | - |
2.7.12.2 | lung cancer cell line | - |
Homo sapiens | - |
2.7.12.2 | pancreatic cancer cell line | - |
Homo sapiens | - |
2.7.12.2 | testicular cancer cell line | human pancreatic, lung, breast, testicle, and colorectal cancer cell lines | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.12.2 | ATP + protein | MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2. The enzyme is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins, additional role for MKK4 in tumor suppression | Homo sapiens | ADP + phosphoprotein | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.12.2 | dual specificity mitogen-activated protein kinase kinase 4 | - |
Homo sapiens |
2.7.12.2 | MKK4 | - |
Homo sapiens |