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Literature summary extracted from

  • Abo, A.; Qu, J.; Cammarano, M.S.; Dan, C.; Fritsch, A.; Baud, V.; Belisle, B.; Minden, A.
    PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia (1998), EMBO J., 17, 6527-6540.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 Golgi membrane coexpression of PAK4 and the constitutively active Cdc42HsV12 causes the redistribution of PAK4 to the brefeldin A-sensitive compartment of the Golgi membrane and the subsequent induction of filopodia and actin polymerization Homo sapiens 139
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + protein Homo sapiens the enzyme is an effector for Cdc42Hs and is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia ADP + phosphoprotein
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens O96013
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + Cdc42Hs PAK4 interacts only with the activated form of Cdc42Hs through its GTPase-binding domain Homo sapiens ADP + ?
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 ?
2.7.11.1 ATP + protein the enzyme is an effector for Cdc42Hs and is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia Homo sapiens ADP + phosphoprotein
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 PAK4
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 Homo sapiens
2.7.11.1 serine/threonine-protein kinase PAK 4
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 Homo sapiens