Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Johnston, A.M.; Naselli, G.; Gonez, L.J.; Martin, R.M.; Harrison, L.C.; DeAizpurua, H.J.
    SPAK, a STE20/SPS1-related kinase that activates the p38 pathway (2000), Oncogene, 19, 4290-4297.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 cytoplasm full-length SPAK is expressed in the cytoplasm in transfected cells Rattus norvegicus 5737
-
2.7.11.1 nucleus in a mutant corresponding to caspase-cleaved SPAK the enzyme is expressed predominantly in the nucleus Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + protein Rattus norvegicus enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals ADP + phosphoprotein
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens Q9UEW8
-
-
2.7.11.1 Mus musculus Q9Z1W9
-
-
2.7.11.1 Rattus norvegicus O88506
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein autophosphorylation Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 brain preferentially expressed in brain and pancreas Rattus norvegicus
-
2.7.11.1 pancreas preferentially expressed in brain and pancreas Rattus norvegicus
-
2.7.11.1 pancreatic beta cell line
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + protein autophosphorylation Rattus norvegicus ADP + phosphoprotein
-
?
2.7.11.1 ATP + protein enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals Rattus norvegicus ADP + phosphoprotein
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 SPAK
-
Rattus norvegicus
2.7.11.1 STE20/SPS1-related proline-alanine rich protein kinase
-
Rattus norvegicus
2.7.11.1 STE20/SPS1-related proline-alanine rich protein kinase
-
Homo sapiens
2.7.11.1 STE20/SPS1-related proline-alanine rich protein kinase
-
Mus musculus
2.7.11.1 STE20/SPS1-related, proline alanine-rich kinase
-
Rattus norvegicus