EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.1 | cytoplasm | full-length SPAK is expressed in the cytoplasm in transfected cells | Rattus norvegicus | 5737 | - |
2.7.11.1 | nucleus | in a mutant corresponding to caspase-cleaved SPAK the enzyme is expressed predominantly in the nucleus | Rattus norvegicus | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.1 | ATP + protein | Rattus norvegicus | enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals | ADP + phosphoprotein | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.1 | Homo sapiens | Q9UEW8 | - |
- |
2.7.11.1 | Mus musculus | Q9Z1W9 | - |
- |
2.7.11.1 | Rattus norvegicus | O88506 | - |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.1 | phosphoprotein | autophosphorylation | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.1 | brain | preferentially expressed in brain and pancreas | Rattus norvegicus | - |
2.7.11.1 | pancreas | preferentially expressed in brain and pancreas | Rattus norvegicus | - |
2.7.11.1 | pancreatic beta cell line | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.1 | ATP + protein | autophosphorylation | Rattus norvegicus | ADP + phosphoprotein | - |
? | |
2.7.11.1 | ATP + protein | enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals | Rattus norvegicus | ADP + phosphoprotein | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.1 | SPAK | - |
Rattus norvegicus |
2.7.11.1 | STE20/SPS1-related proline-alanine rich protein kinase | - |
Rattus norvegicus |
2.7.11.1 | STE20/SPS1-related proline-alanine rich protein kinase | - |
Homo sapiens |
2.7.11.1 | STE20/SPS1-related proline-alanine rich protein kinase | - |
Mus musculus |
2.7.11.1 | STE20/SPS1-related, proline alanine-rich kinase | - |
Rattus norvegicus |