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Literature summary extracted from

  • Kochs, G.; Hummel, R.; Meyer, D.; Hug, H.; Marme, D.; Sarre, T.F.
    Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes (1993), Eur. J. Biochem., 216, 597-606.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 arachidonic acid alone or a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity Homo sapiens
2.7.11.13 arachidonic acid slightly enhances PKC zeta activity Homo sapiens
2.7.11.13 diacylglycerol plus phosphatidylserine, activates Homo sapiens
2.7.11.13 gamma-linolenic acid a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity Homo sapiens
2.7.11.13 additional information cannot be activated by phorbol ester treatment of NIH 3T3 cells or insect cells, overexpressing the respective PKC isoenzyme Homo sapiens
2.7.11.13 phosphatidylserine plus diacylglycerol, activates Homo sapiens
2.7.11.13 phosphatidylserine a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.13 expression in recombinant baculovirus-infected insect cells Homo sapiens
2.7.11.13 expression in recombinant baculovirus-infected insect cells, overexpression in NIH 3T3 cells or insect cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.13 additional information insensitive to PKC inhibitors known to interfere either with the regulatory or the catalytic domain Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.13 Ca2+ activity is independent of Ca2+ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 additional information Homo sapiens constitutive enzyme ?
-
 ?
2.7.11.13 additional information Homo sapiens PKC zeta exhibits a constitutive kinase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Homo sapiens P05129
-
-
2.7.11.13 Homo sapiens Q05513
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.13 partial Homo sapiens
2.7.11.13 partial purification of the PKC-zeta isoenzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + PKC-alpha-derived peptide in the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide Homo sapiens ADP + phosphorylated PKC-alpha-derived peptide
-
 ?
2.7.11.13 additional information constitutive enzyme Homo sapiens ?
-
 ?
2.7.11.13 additional information PKC zeta exhibits a constitutive kinase Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC-zeta
-
 Homo sapiens
2.7.11.13 protein kinase C, gamma type
-
 Homo sapiens
2.7.11.13 protein kinase C, zeta type
-
 Homo sapiens