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Literature summary extracted from

  • Urasawa, K.; Yoshida, I.; Takagi, C.; Onozuka, H.; Mikami, T.; Kawaguchi, H.; Kitabatake, A.
    Enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58 (1996), Biochem. Biophys. Res. Commun., 219, 26-30.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15
-
 Mesocricetus auratus
2.7.11.15 cDNA encoding beta-ARK 1 is cloned from heart and sequenced, 689 amino acids protein, 95% homology to rat and 90% homology to human beta-ARK 1 Mesocricetus auratus
2.7.11.15 nucleotide sequence of beta-ARK 1, 95% homology to Syrian hamster beta-ARK 1 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Rattus norvegicus
-
 ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Mesocricetus auratus beta-ARK 1 might be involved in uncoupling and down-regulation of beta-AR, presumably both beta1- and beta2-AR, in failing hearts via receptor phosphorylation ADP + phospho-beta-adrenergic receptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Mesocricetus auratus
-
 Syrian hamster, healthy F1b and cardiomyopathic BIO53.58, 7, 15 and 20 weeks old, beta-ARK 1
-
2.7.11.15 Mesocricetus auratus Q64682
-
-
2.7.11.15 Rattus norvegicus
-
 beta-ARK 1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 heart
-
 Rattus norvegicus
-
2.7.11.15 heart enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58 Mesocricetus auratus
-
2.7.11.15 heart significantly increased expression of beta-ARK 1 in the hearts of BIO53.58 hamsters compared to control hamsters F1b Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor
-
 Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor beta-ARK 1 might be involved in uncoupling and down-regulation of beta-AR, presumably both beta1- and beta2-AR, in failing hearts via receptor phosphorylation Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 beta-adrenergic receptor kinase 1
-
 Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Rattus norvegicus
2.7.11.15 ATP
-
 Mesocricetus auratus