EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.13 | FTRKRQRAMRRVHQ | autoregulatory pseudosubstrate sequence, residues 24-40, lung enzyme | Homo sapiens | |
2.7.11.13 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Drosophila melanogaster | |
2.7.11.13 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential, sequences of the different enzyme forms, required sequence properties, overview | eukaryota | |
2.7.11.13 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Homo sapiens | |
2.7.11.13 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Saccharomyces cerevisiae | |
2.7.11.13 | NKMKSRLRKGALKKNV | autoregulatory pseudosubstrate sequence, residues 24-40 | Drosophila melanogaster | |
2.7.11.13 | QLMGGLHRHGAIINRKE | autoregulatory pseudosubstrate sequence, residues 391-407 | Saccharomyces cerevisiae | |
2.7.11.13 | Tween 80 | inhibits the enzyme at high concentration | Drosophila melanogaster | |
2.7.11.13 | Tween 80 | inhibits the enzyme at high concentration | eukaryota | |
2.7.11.13 | Tween 80 | inhibits the enzyme at high concentration | Homo sapiens | |
2.7.11.13 | Tween 80 | inhibits the enzyme at high concentration | Saccharomyces cerevisiae | |
2.7.11.17 | ARRKWQKTGHAVRAIGRLSS | calmodulin antagonist peptide, IC50: 33.3 nM in H2O, 10.6 nM in buffer containing 0.1% w/v Tween 80 | eukaryota | |
2.7.11.17 | additional information | synthesis of peptides behaving as autoregulatory pseudosubstrates, determination of inhibitory potential, sequences of autoregulatory regions of the different enzyme forms, required sequence properties, overview | eukaryota | |
2.7.11.18 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | eukaryota | |
2.7.11.18 | SKDRMKKYMARRKWQKTGHAVRAI | autoregulatory pseudosubstrate sequence of smooth muscle enzyme, residues 787-810 | eukaryota | |
2.7.11.18 | SQRLLKKYLMKRRWKKNFIAVSAA | autoregulatory pseudosubstrate sequence of the skeletal muscle enzyme, residues 570-593 | eukaryota | |
2.7.11.19 | LLRDPYALRSVRHLIDNCAFRL | autoregulatory pseudosubstrate sequence of the gamma subunit, residues 336-357 | Homo sapiens | |
2.7.11.19 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Homo sapiens | |
2.7.11.19 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Mus musculus | |
2.7.11.19 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | Oryctolagus cuniculus | |
2.7.11.19 | VIRDPYALPPLRRLIDAYAFRI | autoregulatory pseudosubstrate sequence of the gamma subunit, residues 333-354 | Mus musculus | |
2.7.11.19 | VIRDPYALRPLRRLIDAYAFRI | autoregulatory pseudosubstrate sequence of the gamma subunit, residues 332-353 | Oryctolagus cuniculus | |
2.7.11.24 | (hydroxy-2-naphthalenylmethyl)phosphonic acid | inhibits the insulin receptor tyrosine kinase, IC50 is 0.01 mM | eukaryota | |
2.7.11.24 | additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | eukaryota |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.13 | Mg2+ | - |
Drosophila melanogaster | |
2.7.11.13 | Mg2+ | - |
eukaryota | |
2.7.11.13 | Mg2+ | - |
Homo sapiens | |
2.7.11.13 | Mg2+ | - |
Saccharomyces cerevisiae | |
2.7.11.17 | Ca2+ | binding required for activity | eukaryota | |
2.7.11.18 | Mg2+ | - |
eukaryota | |
2.7.11.19 | Mg2+ | - |
Mus musculus | |
2.7.11.19 | Mg2+ | - |
Homo sapiens | |
2.7.11.19 | Mg2+ | - |
Oryctolagus cuniculus | |
2.7.11.24 | Mg2+ | - |
eukaryota |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.13 | ATP + a protein | Drosophila melanogaster | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.13 | ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.13 | ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.13 | ATP + a protein | Saccharomyces cerevisiae | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.17 | ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.18 | ATP + myosin light chain | eukaryota | - |
ADP + phosphorylated myosin light chain | - |
? | |
2.7.11.19 | ATP + a protein | Mus musculus | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.19 | ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.19 | ATP + a protein | Oryctolagus cuniculus | - |
ADP + a phosphoprotein | - |
? | |
2.7.11.19 | ATP + phosphorylase b | Mus musculus | - |
ADP + phosphorylase a | - |
? | |
2.7.11.19 | ATP + phosphorylase b | Homo sapiens | - |
ADP + phosphorylase a | - |
? | |
2.7.11.19 | ATP + phosphorylase b | Oryctolagus cuniculus | - |
ADP + phosphorylase a | - |
? | |
2.7.11.24 | ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.13 | Drosophila melanogaster | - |
- |
- |
2.7.11.13 | eukaryota | - |
enzyme forms alpha, betaI ans betaII, gamma, epsilon, delta, zeta | - |
2.7.11.13 | Homo sapiens | - |
- |
- |
2.7.11.13 | Saccharomyces cerevisiae | - |
- |
- |
2.7.11.17 | eukaryota | - |
enzyme forms alpha, beta, gamma, delta | - |
2.7.11.18 | eukaryota | - |
- |
- |
2.7.11.19 | Homo sapiens | - |
- |
- |
2.7.11.19 | Mus musculus | - |
- |
- |
2.7.11.19 | Oryctolagus cuniculus | - |
- |
- |
2.7.11.24 | eukaryota | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.17 | phosphoprotein | autophosphorylation at Ser19 | eukaryota |
2.7.11.24 | phosphoprotein | autophosphorylation near the pseudosubstrate site | eukaryota |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.13 | lung | - |
Homo sapiens | - |
2.7.11.18 | skeletal muscle | - |
eukaryota | - |
2.7.11.18 | smooth muscle | - |
eukaryota | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.13 | ATP + a protein | - |
Drosophila melanogaster | ADP + a phosphoprotein | - |
? | |
2.7.11.13 | ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
2.7.11.13 | ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
2.7.11.13 | ATP + a protein | - |
Saccharomyces cerevisiae | ADP + a phosphoprotein | - |
? | |
2.7.11.13 | additional information | substrate specificity | Drosophila melanogaster | ? | - |
? | |
2.7.11.13 | additional information | substrate specificity | eukaryota | ? | - |
? | |
2.7.11.13 | additional information | substrate specificity | Homo sapiens | ? | - |
? | |
2.7.11.13 | additional information | substrate specificity | Saccharomyces cerevisiae | ? | - |
? | |
2.7.11.17 | ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
2.7.11.17 | additional information | substrate specificity | eukaryota | ? | - |
? | |
2.7.11.18 | ATP + myosin light chain | - |
eukaryota | ADP + phosphorylated myosin light chain | - |
? | |
2.7.11.18 | additional information | substrate specificity | eukaryota | ? | - |
? | |
2.7.11.19 | ATP + a protein | - |
Mus musculus | ADP + a phosphoprotein | - |
? | |
2.7.11.19 | ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
2.7.11.19 | ATP + a protein | - |
Oryctolagus cuniculus | ADP + a phosphoprotein | - |
? | |
2.7.11.19 | ATP + phosphorylase b | - |
Mus musculus | ADP + phosphorylase a | - |
? | |
2.7.11.19 | ATP + phosphorylase b | - |
Homo sapiens | ADP + phosphorylase a | - |
? | |
2.7.11.19 | ATP + phosphorylase b | - |
Oryctolagus cuniculus | ADP + phosphorylase a | - |
? | |
2.7.11.19 | additional information | substrate specificity | Mus musculus | ? | - |
? | |
2.7.11.19 | additional information | substrate specificity | Homo sapiens | ? | - |
? | |
2.7.11.19 | additional information | substrate specificity | Oryctolagus cuniculus | ? | - |
? | |
2.7.11.24 | ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
2.7.11.24 | additional information | substrate specificity | eukaryota | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.13 | PKC | - |
Drosophila melanogaster |
2.7.11.13 | PKC | - |
eukaryota |
2.7.11.13 | PKC | - |
Homo sapiens |
2.7.11.13 | PKC | - |
Saccharomyces cerevisiae |
2.7.11.17 | Cam-II PK | - |
eukaryota |
2.7.11.18 | MLCK | - |
eukaryota |
2.7.11.24 | receptor-linked ribosomal protein S6 | - |
eukaryota |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.13 | ATP | - |
Drosophila melanogaster | |
2.7.11.13 | ATP | - |
eukaryota | |
2.7.11.13 | ATP | - |
Homo sapiens | |
2.7.11.13 | ATP | - |
Saccharomyces cerevisiae | |
2.7.11.17 | ATP | - |
eukaryota | |
2.7.11.17 | Calmodulin | binding required for activity | eukaryota | |
2.7.11.18 | ATP | - |
eukaryota | |
2.7.11.19 | ATP | - |
Mus musculus | |
2.7.11.19 | ATP | - |
Homo sapiens | |
2.7.11.19 | ATP | - |
Oryctolagus cuniculus | |
2.7.11.24 | ATP | - |
eukaryota |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.13 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Drosophila melanogaster | |
2.7.11.13 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | eukaryota | |
2.7.11.13 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Homo sapiens | |
2.7.11.13 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Saccharomyces cerevisiae | |
2.7.11.17 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | eukaryota | |
2.7.11.18 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | eukaryota | |
2.7.11.19 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Mus musculus | |
2.7.11.19 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Homo sapiens | |
2.7.11.19 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | Oryctolagus cuniculus | |
2.7.11.24 | additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | eukaryota |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.11.17 | 0.0000333 | - |
calmodulin antagonist peptide, IC50: 33.3 nM in H2O, 10.6 nM in buffer containing 0.1% w/v Tween 80 | eukaryota | ARRKWQKTGHAVRAIGRLSS | |
2.7.11.24 | 0.01 | - |
inhibits the insulin receptor tyrosine kinase, IC50 is 0.01 mM | eukaryota | (hydroxy-2-naphthalenylmethyl)phosphonic acid |