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Literature summary extracted from

  • Baudier, J.; Cole, R.D.
    Phosphorylation of tau proteins to a state like that in Alzheimers brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids (1987), J. Biol. Chem., 262, 17577-17583.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 phosphatidic acid activating at low concentrations, inhibitory at high concentrations Rattus norvegicus
2.7.11.17 phosphatidylethanolamine activation Rattus norvegicus
2.7.11.17 phosphatidylserine activation, addition leads to 100% phosphorylation of tau2-protein Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 phosphatidic acid at high concentrations, activates at low concentrations Rattus norvegicus
2.7.11.17 phosphatidylinositol strong Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ requirement Rattus norvegicus
2.7.11.17 Ca2+ requirement Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.17 50000
-
 x * 50000 + x * 60000, SDS-PAGE Rattus norvegicus
2.7.11.17 50000
-
 x * 50000 + x * 60000, SDS-PAGE Bos taurus
2.7.11.17 60000
-
 x * 50000 + x * 60000, SDS-PAGE Rattus norvegicus
2.7.11.17 60000
-
 x * 50000 + x * 60000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Bos taurus
-
-
-
2.7.11.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.17
-
 Rattus norvegicus
2.7.11.17
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Rattus norvegicus
-
2.7.11.17 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + microtubule-associated protein tau Ca2+/calmodulin dependent autophosphorylation Rattus norvegicus ?
-
 ?
2.7.11.17 ATP + microtubule-associated protein tau Ca2+/calmodulin dependent autophosphorylation Bos taurus ?
-
 ?
2.7.11.17 ATP + microtubule-associated protein tau all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation Rattus norvegicus ?
-
 ?
2.7.11.17 ATP + microtubule-associated protein tau all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 ? x * 50000 + x * 60000, SDS-PAGE Rattus norvegicus
2.7.11.17 ? x * 50000 + x * 60000, SDS-PAGE Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 Calmodulin requirement Rattus norvegicus
2.7.11.17 Calmodulin requirement Bos taurus