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Literature summary extracted from

  • Hannonen, P.; Jänne, J.; Raina, A.
    Partial purification and characterization of spermine synthase from rat brain (1972), Biochim. Biophys. Acta, 289, 225-231.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.22 putrescine
-
 Rattus norvegicus
2.5.1.22 spermine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.22 0.005
-
 S-adenosylmethioninamine
-
 Rattus norvegicus
2.5.1.22 0.07
-
 spermidine
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.22 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.22 additional information no metal ion requirement Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Rattus norvegicus
-
 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Rattus norvegicus Wistar
-
 5'-methylthioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Rattus norvegicus
-
-
-
2.5.1.22 Rattus norvegicus
-
 Wistar
-
2.5.1.22 Rattus norvegicus Wistar
-
 Wistar
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.22 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 brain
-
 Rattus norvegicus
-
2.5.1.22 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.22 0.306
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus Wistar 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus Wistar 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus 5'-methylthioadenosine + spermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus Wistar 5'-methylthioadenosine + spermine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.22 additional information
-
 pI: 5 Rattus norvegicus
2.5.1.22 7.5 8.1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.22 additional information no cofactor requirement Rattus norvegicus