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Literature summary extracted from

  • Pegg, A.E.; Shuttleworth, K.; Hibasami, H.
    Specificity of mammalian spermidine synthase and spermine synthase (1981), Biochem. J., 197, 315-320.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.22 0.02
-
 spermidine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Rattus norvegicus i.e. S-adenosylmethioninamine or decarboxylated S-adenosylmethionine + putrescine, involved in polyamine biosynthetic pathway 5'-methylthioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Rattus norvegicus
-
-
-
2.5.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 prostate gland
-
 Rattus norvegicus
-
2.5.1.22 prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,3-diaminopentane poor substrate Rattus norvegicus ?
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane i.e. S-adenosylmethioninamine or decarboxylated S-adenosylmethionine + putrescine, involved in polyamine biosynthetic pathway Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
-
 Rattus norvegicus 5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
 ?
2.5.1.22 additional information overview Rattus norvegicus ?
-
 ?
2.5.1.22 additional information no substrates are putrescine, cadaverine, spermine, sym-norspermine, spermidine monoacetyl derivatives Rattus norvegicus ?
-
 ?
2.5.1.22 S-adenosylmethioninamine + 1,8-diaminooctane poor substrate Rattus norvegicus 5'-methylthioadenosine + N-(3-aminopropyl)octane-1,8-diamine
-
 ?
2.5.1.22 S-adenosylmethioninamine + N-(3-aminopropyl)cadaverine poor substrate Rattus norvegicus 5'-methylthioadenosine + ?
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine best substrate Rattus norvegicus 5'-methylthioadenosine + spermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + sym-homospermidine 17% of the activity with spemidine Rattus norvegicus 5'-methylthioadenosine + ?
-
 ?
2.5.1.22 S-adenosylmethioninamine + sym-norspermidine poor substrate Rattus norvegicus 5'-methylthioadenosine + ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.16 37
-
 assay at Rattus norvegicus