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Literature summary extracted from

  • Elliott, G.C.; Rechsteiner, M.C.
    Evidence for a physiologically active nicotinamide phosphoribosyltransferase in cultured human fibroblasts (1982), Biochem. Biophys. Res. Commun., 104, 996-1002.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.4.2.12 freeze-thawing inactivates Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 additional information nicotinic acid, thymine, 5-bromouracil Homo sapiens
2.4.2.12 NAD+
-
Homo sapiens
2.4.2.12 nicotinate adenine dinucleotide not inhibitory Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.12 0.0016
-
nicotinamide
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.12 soluble
-
Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.12 Mg2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 fibroblast diploid, GM 1362, from patient with Lesch-Nyhan disease Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
2.4.2.12 -80°C, crude, 4-6 months Homo sapiens
2.4.2.12 4°C, crude, inactivation overnight Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate specific for nicotinamide, no substrates: thymine, 5-bromouracil, nicotinic acid adenine dinucleotide Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.12 37
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.4.2.12 ATP requirement Homo sapiens