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Literature summary extracted from

  • Irshaid, Y.M.; Tephly, T.R.
    Isolation and purification of two human liver UDP-glucuronosyltransferases (1987), Mol. Pharmacol., 31, 27-34.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 phosphatidylcholine required by purified preparations for optimal activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.17 53000
-
 x * 53000, isozyme 1 Homo sapiens
2.4.1.17 54000
-
 x * 54000, isozyme 2 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.17 two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography Homo sapiens

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.4.1.17 phospholipid required for reconstitution Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 4-aminobiphenyl + UDPglucuronate catalyzed by isozyme 1 but not by isozyme 2 Homo sapiens UDP + ?
-
 ?
2.4.1.17 4-methylumbelliferone + UDP-glucuronate
-
 Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
 ?
2.4.1.17 4-nitrophenol + UDP-glucuronate
-
 Homo sapiens 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
2.4.1.17 alpha-naphthylamine + UDPglucuronate
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 beta-estradiol + UDPglucuronate inactive Homo sapiens beta-estradiol-3-glucuronide + UDP
-
 ?
2.4.1.17 estriol + UDPglucuronate catalyzed by isozyme 1 but not by isozyme 2 Homo sapiens UDP + estriol-16 alpha-glucuronide
-
 ?
2.4.1.17 estrone + UDPglucuronate inactive Homo sapiens UDP + estrone 3-O-glucuronide
-
 ?
2.4.1.17 additional information 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids Homo sapiens ?
-
 ?
2.4.1.17 additional information no activity with androsterone, 5alpha-androstane-3alpha,17beta-diol Homo sapiens ?
-
 ?
2.4.1.17 testosterone + UDPglucuronate no activity Homo sapiens UDP + testosterone O-glucuronide
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.17 ? x * 54000, isozyme 2 Homo sapiens
2.4.1.17 ? x * 53000, isozyme 1 Homo sapiens
2.4.1.17 ? all values determined by SDS-PAGE Homo sapiens