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Literature summary extracted from

  • Zakim, D.; Vessey, D.A.
    The properties of uridine diphosphate glucuronyltransferase(s) which catalyse the synthesis of steroid glucuronides in microsomal fractions from guinea-pig liver (1976), Biochem. J., 157, 667-673.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 Mersalyl maximal activation towards estrone, estradiol and testosterone at 1 mM Cavia porcellus
2.4.1.17 Phospholipase A stimulation of glucuronidation of estradiol and estrone, inhibition of glucuronidation of testosterone in whole microsomes Cavia porcellus
2.4.1.17 UDP-N-acetylglucosamine no significant activation towards steroids as aglycones Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 Phospholipase A potentiates end-product inhibition in whole microsomes: inhibition of glucuronidation of testosterone, stimulation of glucuronidation of estradiol and estrone Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Cavia porcellus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mn2+ 1 mM, activation Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Cavia porcellus
-
 domestic guinea pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 estrone + UDPglucuronate
-
 Cavia porcellus UDP + estrone 3-O-glucuronide
-
 ?
2.4.1.17 testosterone + UDPglucuronate
-
 Cavia porcellus UDP + testosterone O-glucuronide
-
 ?