Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Koster, A.S.; Noordhoek, J.
    Kinetic properties of the rat intestinal microsomal 1-naphthol:UDP-glucuronosyl transferase. Inhibition by UDP and UDP-N-acetylglucosamine (1983), Biochim. Biophys. Acta, 761, 76-85.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 Triton X-100 activation Rattus norvegicus
2.4.1.17 UDP-N-acetylglucosamine small activation towards 1-naphthol in MgCl2 activated microsomes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 UDP end product mixed type inhibition towards UDPglucuronic acid and 1-naphthol in latent or partially MgCl2 activated microsomes Rattus norvegicus
2.4.1.17 UDP-N-acetylglucosamine full competitive inhibition towards UDPglucuronic acid, mixed-type inhibition towards 1-naphthol Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.012
-
 testosterone 1-naphthol added, in presence of 5 mM MgCl2 as activator Rattus norvegicus
2.4.1.17 0.015
-
 1-naphthol no activator present Rattus norvegicus
2.4.1.17 0.03
-
 1-naphthol presence of 50 mM MgCl2 as activator Rattus norvegicus
2.4.1.17 0.067
-
 1-naphthol presence of 50 mM MgCl2, 0.1% Triton X-100 as activator Rattus norvegicus
2.4.1.17 0.37
-
 UDPglucuronate 2 mM 1-naphthol added, in presence of 50 mM MgCl2 Rattus norvegicus
2.4.1.17 0.59
-
 UDPglucuronate 0.2 mM 1-naphthol added, no activator present Rattus norvegicus
2.4.1.17 0.71
-
 UDPglucuronate 0.2 mM 1-naphthol added, in presence of 50 mM MgCl2, 0.1% Triton X-100 as activator Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ 50 mM, activation Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Rattus norvegicus
-
 Wistar strain
-
2.4.1.17 Rattus norvegicus Wistar
-
 Wistar strain
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.1.17 UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside sequential bireactant mechanism Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 small intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 1-naphthol + UDP-glucuronate
-
 Rattus norvegicus naphth-1-yl-beta-D-glucuronide + UDP
-
 ?
2.4.1.17 1-naphthol + UDP-glucuronate
-
 Rattus norvegicus Wistar naphth-1-yl-beta-D-glucuronide + UDP
-
 ?
2.4.1.17 testosterone + UDPglucuronate
-
 Rattus norvegicus UDP + testosterone O-glucuronide
-
 ?
2.4.1.17 testosterone + UDPglucuronate
-
 Rattus norvegicus Wistar UDP + testosterone O-glucuronide
-
 ?