EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.17 | 3-methylcholanthrene | several-fold activity enhanced of 1-naphthol, 4-nitrophenol, N-hydroxy-2-naphtylamine and 3-hydroxy benzo[a]pyrene | Rattus norvegicus | |
2.4.1.17 | lysophosphatidylcholine | slight stimulation of highly purified preparations | Rattus norvegicus | |
2.4.1.17 | Phenobarbital | stimulates action against 4-hydroxybiphenyl, chloramphenicol and bilirubin | Rattus norvegicus | |
2.4.1.17 | UDP-N-acetylglucosamine | no effect on the purified enzyme | Rattus norvegicus | |
2.4.1.17 | UDP-N-acetylglucosamine | physiological activator of UDPGT in the latent membrane-bond state of the enzyme without effect on the purified enzyme | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.17 | UDP | - |
Rattus norvegicus | |
2.4.1.17 | UDPgalacturonic acid | slight effect | Rattus norvegicus | |
2.4.1.17 | UDPglucose | slight effect | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.17 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.17 | Mg2+ | 2fold activation of purified enzyme | Rattus norvegicus | |
2.4.1.17 | Mg2+ | as MgCl2: 5 mM, activation | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.1.17 | 54000 | - |
1-naphthol-UDPGT by SDS-PAGE | Rattus norvegicus |
2.4.1.17 | 56000 | - |
x * 56000, phenobarbital-inducible isozyme | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.17 | Rattus norvegicus | - |
Wistar strain | - |
2.4.1.17 | Rattus norvegicus Wistar | - |
Wistar strain | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.17 | purification of two isozymes inducibles by 3-methylcholanthrene or phenobarbital using sodium cholate solubilization, chromatography on Bio Gel A 1.5 m, DEAE-cellulose and UDP-hexanolamine Sepharose 4B | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.17 | adrenal gland | - |
Rattus norvegicus | - |
2.4.1.17 | kidney | - |
Rattus norvegicus | - |
2.4.1.17 | liver | - |
Rattus norvegicus | - |
2.4.1.17 | lung | - |
Rattus norvegicus | - |
2.4.1.17 | skin | - |
Rattus norvegicus | - |
2.4.1.17 | small intestine | - |
Rattus norvegicus | - |
2.4.1.17 | spleen | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.4.1.17 | additional information | - |
comparison of activities between differentially inducible forms | Rattus norvegicus |
2.4.1.17 | 0.67 | - |
morphine as substrate, Wistar strain treated with phenobarbital | Rattus norvegicus |
2.4.1.17 | 5.35 | - |
1-naphthol as substrate, Wistar strain treated with phenobarbital | Rattus norvegicus |
2.4.1.17 | 6.06 | - |
1-naphthol as substrate, Wistar strain treated with 3-methylcholanthrene | Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
2.4.1.17 | 0-4°C, 0.1 mg/ml lysophosphatidylcholine, 1 mM EDTA, 11% loss of activity in 6 days, 20% loss of activity in 12 days | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.17 | 1-naphthol + UDP-glucuronate | - |
Rattus norvegicus | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | 1-naphthol + UDP-glucuronate | - |
Rattus norvegicus Wistar | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | 3-hydroxybenzo[a]pyrene + UDPglucuronate | - |
Rattus norvegicus | UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide | - |
? | |
2.4.1.17 | 4-hydroxybiphenyl + UDP-glucuronate | - |
Rattus norvegicus | UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide | - |
? | |
2.4.1.17 | 4-nitrophenol + UDP-glucuronate | - |
Rattus norvegicus | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | 4-nitrophenol + UDP-glucuronate | - |
Rattus norvegicus Wistar | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | estrone + UDPglucuronate | - |
Rattus norvegicus | UDP + estrone 3-O-glucuronide | - |
? | |
2.4.1.17 | additional information | specificity not influenced by lysophosphatidylcholine | Rattus norvegicus | ? | - |
? | |
2.4.1.17 | additional information | specificity not influenced by lysophosphatidylcholine | Rattus norvegicus Wistar | ? | - |
? | |
2.4.1.17 | morphine + UDP-glucuronate | - |
Rattus norvegicus | UDP + morphine 3,6-diglucuronide | - |
? | |
2.4.1.17 | morphine + UDP-glucuronate | - |
Rattus norvegicus Wistar | UDP + morphine 3,6-diglucuronide | - |
? | |
2.4.1.17 | N-hydroxy-2-naphthylamine + UDPglucuronate | - |
Rattus norvegicus | UDP + N-hydroxy-2-naphthylamine-O-glucuronide | - |
? | |
2.4.1.17 | N-hydroxy-2-naphthylamine + UDPglucuronate | - |
Rattus norvegicus Wistar | UDP + N-hydroxy-2-naphthylamine-O-glucuronide | - |
? | |
2.4.1.17 | testosterone + UDPglucuronate | - |
Rattus norvegicus | UDP + testosterone O-glucuronide | - |
? | |
2.4.1.17 | UDP-alpha-D-glucuronate + chloramphenicol | - |
Rattus norvegicus | UDP + chloramphenicol beta-D-glucuronide | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.1.17 | ? | x * 56000, phenobarbital-inducible isozyme | Rattus norvegicus |
2.4.1.17 | ? | additional values for rat isozymes ranging from 51000 to 59000 | Rattus norvegicus |
2.4.1.17 | ? | x * 54000, methylcholanthrene-inducible isozyme | Rattus norvegicus |
2.4.1.17 | ? | all values determined by SDS-PAGE | Rattus norvegicus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.17 | -20 | - |
rapid loss of activity | Rattus norvegicus |