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Literature summary extracted from

  • Malagolini, N.; Dall'Olio, F.; Serafini-Cessi, F.
    UDP-GalNAc: NeuAc alpha 2,3Gal beta-R (GalNAc to Gal) beta 1,4-N-acetylgalactosaminyltransferase responsible for the Sda specificity in human colon carcinoma CaCo-2 cell line (1991), Biochem. Biophys. Res. Commun., 180, 681-686.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.165 Triton X-100 activation Homo sapiens

Application

EC Number Application Comment Organism
2.4.1.165 analysis the enzyme is a marker of the colonic cell maturation Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.165 Mn2+ optimal concentration is 10 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.165 UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Homo sapiens responsible for addition of the immunodominant sugar of the Sda-isto-blood-group determinant UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.165 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.165 Caco-2 cell
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 Homo sapiens
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2.4.1.165 large intestine colon mucosa or colon carcinoma cell line CaCo-2, not in cell lines SW-948, SW-948FL, SW-480, SW-48, SW-1417, COLO-205, LOVO or HT-29 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.165 UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide responsible for addition of the immunodominant sugar of the Sda-isto-blood-group determinant Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?
2.4.1.165 UDP-N-acetyl-D-galactosamine + asialofetuin
-
 Homo sapiens UDP + N-acetylgalactosaminylasialofetuin
-
 ?
2.4.1.165 UDP-N-acetyl-D-galactosamine + fetuin
-
 Homo sapiens UDP + N-acetylgalactosaminylfetuin
-
 ?
2.4.1.165 UDP-N-acetyl-D-galactosamine + glycophorin good acceptor Homo sapiens UDP + N-acetylgalactosaminyl glycophorin
-
 ?
2.4.1.165 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin
-
 Homo sapiens UDP + N-acetylgalactosaminyl human chorionic gonadotropin
-
 ?
2.4.1.165 UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc strictly requires the presence of sialic acid in alpha-2,3-linkage to subterminal galactose Homo sapiens UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.165 7.5
-
-
 Homo sapiens