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Literature summary extracted from

  • Pugazhenthi, S.; Khandelwal, R.L.
    Regulation of glycogen synthase activation in isolated hepatocytes (1995), Mol. Cell. Biochem., 149-150, 95-101.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.11 aspartate increased uptake leads to activation Mammalia
2.4.1.11 D-glucose
-
Mammalia
2.4.1.11 D-glucose
-
Rattus norvegicus
2.4.1.11 dihydroxyacetone increase of activity Mammalia
2.4.1.11 fructose increase of activity Mammalia
2.4.1.11 galactose increase of activity Mammalia
2.4.1.11 glutamate increased uptake leads to activation Mammalia
2.4.1.11 Insulin
-
Rattus norvegicus
2.4.1.11 Insulin inhibits phosphorylation by kinases and synthase phospatase Mammalia
2.4.1.11 mannose increase of activity Mammalia
2.4.1.11 proline increased uptake leads to activation Mammalia
2.4.1.11 propionate significant activation Ovis aries
2.4.1.11 staurosporine
-
Mammalia
2.4.1.11 xylitol increase of activity Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.11 CaCl2
-
Mammalia
2.4.1.11 calyculin A
-
Mammalia
2.4.1.11 Cl-
-
Mammalia
2.4.1.11 epinephrine leads to phosphorylation of enzyme Mammalia
2.4.1.11 glucagon leads to phosphorylation of enzyme Mammalia
2.4.1.11 microcystin
-
Mammalia
2.4.1.11 okadaic acid
-
Mammalia
2.4.1.11 Oxytocin leads to phosphorylation of enzyme Rattus norvegicus
2.4.1.11 Phorbol esters
-
Mammalia
2.4.1.11 Vasopressin leads to phosphorylation of enzyme Mammalia

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.11 Li+
-
Mammalia
2.4.1.11 additional information
-
Oryctolagus cuniculus
2.4.1.11 additional information regulation of enzyme activity Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen Mammalia
-
glycogen + UDP
-
?
2.4.1.11 UDP-glucose + glycogen Rattus norvegicus
-
glycogen + UDP
-
?
2.4.1.11 UDP-glucose + glycogen Oryctolagus cuniculus
-
glycogen + UDP
-
?
2.4.1.11 UDP-glucose + glycogen Ovis aries
-
glycogen + UDP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.11 Mammalia
-
-
-
2.4.1.11 Oryctolagus cuniculus
-
-
-
2.4.1.11 Ovis aries
-
sheep
-
2.4.1.11 Rattus norvegicus
-
diabetic rats
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.11 phosphoprotein
-
Rattus norvegicus
2.4.1.11 phosphoprotein phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme Mammalia
2.4.1.11 phosphoprotein phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme Oryctolagus cuniculus
2.4.1.11 phosphoprotein multiple phosphorylations on serine residues leads to inactivation Mammalia
2.4.1.11 phosphoprotein phosphorylation at more than 10 sites Oryctolagus cuniculus
2.4.1.11 phosphoprotein phosphorylation leads to loss of activity Mammalia
2.4.1.11 phosphoprotein phosphorylation leads to loss of activity Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.11 hepatocyte
-
Rattus norvegicus
-
2.4.1.11 hepatocyte
-
Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen
-
Mammalia glycogen + UDP
-
?
2.4.1.11 UDP-glucose + glycogen
-
Rattus norvegicus glycogen + UDP
-
?
2.4.1.11 UDP-glucose + glycogen
-
Oryctolagus cuniculus glycogen + UDP
-
?
2.4.1.11 UDP-glucose + glycogen
-
Ovis aries glycogen + UDP
-
?

Subunits

EC Number Subunits Comment Organism
2.4.1.11 ?
-
Rattus norvegicus
2.4.1.11 ?
-
Oryctolagus cuniculus
2.4.1.11 ? x * 80000-93000 Mammalia