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Literature summary extracted from

  • Huang, K.P.; Robinson, J.C.
    Purification and properties of the glucose-6-phosphate-dependent form of human placental glycogen synthase (1976), Arch. Biochem. Biophys., 175, 583-589.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.11 galactose 6-phosphate 57% of the glucose-6-phosphate activation Homo sapiens
2.4.1.11 glucosamine 6-phosphate 50% of the glucose-6-phosphate activation Homo sapiens
2.4.1.11 glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.11 (NH4)2SO4 20% inactivation at 20 mM Homo sapiens
2.4.1.11 phosphate Mg2+, Ca2+ or Mn2+ relieves inhibition Homo sapiens
2.4.1.11 SO42- Mg2+, Ca2+ or Mn2+ relieves inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.11 additional information
-
 additional information dependence on glucose 6-phosphate concentration Homo sapiens
2.4.1.11 0.57 1.25 UDP-glucose value dependent on the presence of glucose 6-phosphate Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.11 Ca2+ activation in presence of glucose 6-phosphate Homo sapiens
2.4.1.11 CaSO4 to a lesser extent, absence of glucose-6-phosphate Homo sapiens
2.4.1.11 CoSO4 absence of glucose-6-phosphate Homo sapiens
2.4.1.11 FeSO4 to a lesser extent, absence of glucose-6-phosphate Homo sapiens
2.4.1.11 KCl activation in presence of glucose 6-phosphate Homo sapiens
2.4.1.11 Mg2+ activation in presence of glucose 6-phosphate Homo sapiens
2.4.1.11 MgSO4 to a lesser extent, absence of glucose-6-phosphate Homo sapiens
2.4.1.11 Mn2+ activation in presence of glucose 6-phosphate Homo sapiens
2.4.1.11 MnSO4 absence of glucose-6-phosphate Homo sapiens
2.4.1.11 NaCl activation in presence of glucose 6-phosphate Homo sapiens
2.4.1.11 NH4Cl activation in presence of glucose 6-phosphate Homo sapiens
2.4.1.11 NiSO4 absence of glucose-6-phosphate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen Homo sapiens
-
 glycogen + UDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.11 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.11 phosphoprotein interconversion of D form to I form is Mn2+ dependent Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.11 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.11 14.13
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.4.1.11 -20°C, 45 mM Tris/HCl buffer, pH 7.5, 1 mM DTT, 10% glycerol, several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen
-
 Homo sapiens glycogen + UDP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.11 5.5 9.2 synthase D, presence of glucose 6-phosphate Homo sapiens
2.4.1.11 7 8.5 synthase D, absence of glucose 6-phosphate Homo sapiens