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Literature summary extracted from

  • Miziorko, H.M.; Clinkenbeard, K.D.; Reed, W.D.; Lane, M.D.
    3-Hydroxy-3-methylglutaryl coenzyme A synthase (1975), J. Biol. Chem., 250, 5768-5773.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.3.10 chloride
-
 Saccharomyces cerevisiae
2.3.3.10 potassium phosphate
-
 Saccharomyces cerevisiae
2.3.3.10 Sodium phosphate
-
 Saccharomyces cerevisiae
2.3.3.10 sulfate
-
 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.10 acetoacetyl-CoA
-
 Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.3.10 53000
-
 2 * 53000, SDS-PAGE Gallus gallus
2.3.3.10 105000
-
 sedimentation equlibrium Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Gallus gallus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Saccharomyces cerevisiae
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.10 Gallus gallus
-
-
-
2.3.3.10 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.3.10 partially Saccharomyces cerevisiae

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.10 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.10 acetyl-CoA + 3'-dephospho-CoA + H2O
-
 Gallus gallus acetyldephospho-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Saccharomyces cerevisiae (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + cysteamine + H2O
-
 Gallus gallus ? + CoA
-
 ?
2.3.3.10 acetyl-CoA + H2O
-
 Gallus gallus acetate + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.3.10 dimer 2 * 53000, SDS-PAGE Gallus gallus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.3.10 0.008
-
 acetoacetyl-CoA
-
 Saccharomyces cerevisiae