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Literature summary extracted from

  • Busby, W.H.; Quackenbush, G.E.; Humm, J.; Youngblood, W.W.; Kizer, J.S.
    An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes (1987), J. Biol. Chem., 262, 8532-8536.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.5 EDTA stimulates Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.5 1,10-phenanthroline 2 mM, complete inhibition Sus scrofa
2.3.2.5 6-methylpterin
-
 Sus scrofa
2.3.2.5 ascorbate
-
 Sus scrofa
2.3.2.5 CuCl2 0.1 mM Sus scrofa
2.3.2.5 FADH2 2 mM Sus scrofa
2.3.2.5 NEM
-
 Sus scrofa
2.3.2.5 NiCl2 0.1 mM Sus scrofa
2.3.2.5 ZnCl2 0.1 mM Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.5 additional information
-
 additional information
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.5 chromaffin granule
-
 Bos taurus 42583
-
2.3.2.5 vesicular fraction
-
 Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.5 55000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.5 L-glutaminyl-peptide Homo sapiens involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Rattus norvegicus involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Sus scrofa involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Bos taurus involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Bos taurus
-
-
-
2.3.2.5 Homo sapiens
-
-
-
2.3.2.5 Rattus norvegicus
-
 neonatal
-
2.3.2.5 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.5 glycoprotein
-
 Homo sapiens
2.3.2.5 glycoprotein
-
 Rattus norvegicus
2.3.2.5 glycoprotein
-
 Sus scrofa
2.3.2.5 glycoprotein
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.5 adrenal medulla
-
 Bos taurus
-
2.3.2.5 B-lymphocyte secretory and non-secretory cell line P3X63Ag8 Homo sapiens
-
2.3.2.5 brain
-
 Rattus norvegicus
-
2.3.2.5 brain
-
 Bos taurus
-
2.3.2.5 pituitary gland
-
 Homo sapiens
-
2.3.2.5 pituitary gland
-
 Sus scrofa
-
2.3.2.5 pituitary gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.5 L-glutaminyl-peptide thyrotropin-releasing hormone Homo sapiens 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide thyrotropin-releasing hormone Rattus norvegicus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide thyrotropin-releasing hormone Sus scrofa 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide thyrotropin-releasing hormone Bos taurus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Homo sapiens 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Rattus norvegicus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Sus scrofa 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Bos taurus 5-oxoprolyl-peptide + NH3
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.2.5 7.2 7.5
-
 Sus scrofa