EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.2 | Maleate | - |
Rattus norvegicus | |
2.3.2.2 | Maleate | stimulates hydrolase reaction 3fold, inhibits transpeptidase reaction, with L-Glu as substrate | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.2 | 6-diazo-5-oxo-L-norleucine | 5-glutamyl-donor, protect transpeptidase and hydrolase activity, not 5-carbon derivative; i.e. DON, strong, irreversible modification of glutamyl-binding site of light subunit | Homo sapiens | |
2.3.2.2 | 6-diazo-5-oxo-L-norleucine | - |
Rattus norvegicus | |
2.3.2.2 | L-azaserine | irreversible inactivation; not 5-carbon derivative; transpeptidase and hydrolase reaction, glutamyl-donor protects | Homo sapiens | |
2.3.2.2 | L-azaserine | irreversible inactivation | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.2.2 | additional information | - |
amino acid composition | Homo sapiens |
2.3.2.2 | additional information | - |
amino acid composition | Rattus norvegicus |
2.3.2.2 | 22000 | - |
1 * 62000 + 1 * 22000, SDS-PAGE | Homo sapiens |
2.3.2.2 | 62000 | - |
1 * 62000 + 1 * 22000, SDS-PAGE | Homo sapiens |
2.3.2.2 | 86000 | - |
gel filtration | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.2.2 | Homo sapiens | - |
- |
- |
2.3.2.2 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.3.2.2 | glycoprotein | - |
Homo sapiens |
2.3.2.2 | glycoprotein | - |
Rattus norvegicus |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.2.2 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.2.2 | kidney | - |
Homo sapiens | - |
2.3.2.2 | kidney | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.2.2 | 800 | - |
purified enzyme | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is 5-L-Glu-4-nitroanilide | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is 5-L-Glu-4-nitroanilide | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | acceptors are amino acids or dipeptides | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | acceptors are amino acids or dipeptides | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | acceptor specificity, overview | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | acceptor specificity, overview | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is GSH | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is GSH | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: S-acetophenoneglutathione | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: S-acetophenoneglutathione | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: S-acetylglutathione | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + glycylglycine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamylglycylglycine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + glycylglycine | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamylglycylglycine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-alanine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamyl-L-alanine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-alanine | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamyl-L-alanine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-asparagine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamyl-L-asparagine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-glutamate | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamyl-L-glutamate | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-glutamate | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamyl-L-glutamate | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-glutamine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamyl-L-glutamine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-glutamine | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamyl-L-glutamine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-methionine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamyl-L-methionine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-methionine | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamyl-L-methionine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-serine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamyl-L-serine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-serine | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamyl-L-serine | - |
? | |
2.3.2.2 | glutathione + acceptor | - |
Homo sapiens | cysteinylglycine + 5-L-glutamyl-acceptor | - |
? | |
2.3.2.2 | glutathione + acceptor | - |
Rattus norvegicus | cysteinylglycine + 5-L-glutamyl-acceptor | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.2.2 | dimer | - |
Rattus norvegicus |
2.3.2.2 | dimer | 1 * 62000 + 1 * 22000, SDS-PAGE | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.2.2 | 37 | - |
assay at | Homo sapiens |
2.3.2.2 | 37 | - |
assay at | Rattus norvegicus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.2.2 | 1150 | - |
4-nitroanilide | - |
Homo sapiens | |
2.3.2.2 | 1250 | - |
4-nitroanilide | - |
Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.2.2 | additional information | - |
- |
Rattus norvegicus |
2.3.2.2 | additional information | - |
several isozymic forms with different content of sialic acid | Homo sapiens |