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Literature summary extracted from

  • Greenberg, C.S.; Birckbichler, P.J.; Rice, R.H.
    Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues (1991), FASEB J., 5, 3071-3077.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.13 thrombin
-
 Cavia porcellus
2.3.2.13 thrombin
-
 Mus musculus
2.3.2.13 thrombin
-
 Homo sapiens
2.3.2.13 thrombin
-
 Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.13 cloning of placenta FXIIIa-gene cDNA Homo sapiens
2.3.2.13 factor XIII, transglutaminase C and transglutaminase K Homo sapiens
2.3.2.13 liver transglutaminase C Cavia porcellus
2.3.2.13 transglutaminase C from macrophage Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 GTP inhibition of tissue transglutaminase Cavia porcellus
2.3.2.13 GTP inhibition of tissue transglutaminase Homo sapiens
2.3.2.13 GTP inhibition of tissue transglutaminase Mus musculus
2.3.2.13 GTP inhibition of tissue transglutaminase Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.13 cytoplasm tissue transglutaminase, factor XIIIa Cavia porcellus 5737
-
2.3.2.13 cytoplasm tissue transglutaminase, factor XIIIa Mus musculus 5737
-
2.3.2.13 cytoplasm tissue transglutaminase, factor XIIIa Homo sapiens 5737
-
2.3.2.13 cytoplasm tissue transglutaminase, factor XIIIa Rattus norvegicus 5737
-
2.3.2.13 membrane
-
 Rattus norvegicus 16020
-
2.3.2.13 membrane keratocytes Homo sapiens 16020
-
2.3.2.13 particle-bound
-
 Cavia porcellus
-
-
2.3.2.13 particle-bound
-
 Homo sapiens
-
-
2.3.2.13 particle-bound on the surface of monocytes and tissue macrophages Mus musculus
-
-
2.3.2.13 particle-bound tissue transglutaminase of rat hepatocytes Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ requirement Cavia porcellus
2.3.2.13 Ca2+ requirement Mus musculus
2.3.2.13 Ca2+ requirement Homo sapiens
2.3.2.13 Ca2+ requirement Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.13 80000
-
 alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence Homo sapiens
2.3.2.13 83005
-
 alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
-
-
2.3.2.13 Homo sapiens
-
-
-
2.3.2.13 Mus musculus
-
-
-
2.3.2.13 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.13 lipoprotein membrane-bound enzyme of keratocytes is anchored via palmitate and myristate Homo sapiens
2.3.2.13 additional information no glycoprotein Cavia porcellus
2.3.2.13 additional information no glycoprotein Mus musculus
2.3.2.13 additional information no glycoprotein Homo sapiens
2.3.2.13 additional information no glycoprotein Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Cavia porcellus
a
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Mus musculus
a
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Homo sapiens
a
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 endothelium
-
 Homo sapiens
-
2.3.2.13 epidermis
-
 Cavia porcellus
-
2.3.2.13 epidermis
-
 Mus musculus
-
2.3.2.13 epidermis callus, keratinocytes Homo sapiens
-
2.3.2.13 hair follicle
-
 Cavia porcellus
-
2.3.2.13 hair follicle
-
 Mus musculus
-
2.3.2.13 hair follicle outer root shear cells Homo sapiens
-
2.3.2.13 hepatocyte
-
 Rattus norvegicus
-
2.3.2.13 liver
-
 Cavia porcellus
-
2.3.2.13 liver
-
 Mus musculus
-
2.3.2.13 liver
-
 Homo sapiens
-
2.3.2.13 liver
-
 Rattus norvegicus
-
2.3.2.13 macrophage
-
 Mus musculus
-
2.3.2.13 additional information tissue distribution Cavia porcellus
-
2.3.2.13 additional information tissue distribution Mus musculus
-
2.3.2.13 additional information tissue distribution Homo sapiens
-
2.3.2.13 additional information tissue distribution Rattus norvegicus
-
2.3.2.13 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrate fibronectin Cavia porcellus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrate fibronectin Mus musculus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrate fibronectin Homo sapiens protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrate fibronectin Rattus norvegicus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine catalyzes post-translational protein modifications by transamidation of glutamine residues Cavia porcellus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine catalyzes post-translational protein modifications by transamidation of glutamine residues Mus musculus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine catalyzes post-translational protein modifications by transamidation of glutamine residues Homo sapiens protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine catalyzes post-translational protein modifications by transamidation of glutamine residues Rattus norvegicus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Cavia porcellus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Mus musculus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Rattus norvegicus protein N5-alkylglutamine + NH3 resulting bonds are covalent and stable to proteolysis ?

Subunits

EC Number Subunits Comment Organism
2.3.2.13 More zymogens of plasma and platelet-coagulation factor XIIIa with different subunit structure: alpha2beta2 and alpha2, respectively Homo sapiens
2.3.2.13 tetramer alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.2.13 Laki-Lorand factor
-
 Homo sapiens