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Literature summary extracted from

  • Gordon, J.I.; Duronio, R.J.; Rudnick, D.A.; Adams, S.P.; Gokel, G.W.
    Protein N-myristoylation (1991), J. Biol. Chem., 266, 8647-8650.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.97 expression in Escherichia coli Saccharomyces cerevisiae
2.3.1.97 expression of mutant nmt1-181 in Escherichia coli Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.97 D451K site-directed mutagenesis, no functional complementation of enzyme deficient nmt1-181 mutant at 36°C Saccharomyces cerevisiae
2.3.1.97 D451N site-directed mutagenesis, no functional complementation of enzyme deficient nmt1-181 mutant at 36°C Saccharomyces cerevisiae
2.3.1.97 E167K site-directed mutagenesis, coexpression of wild-type with Asp451, functional complementation of enzyme deficient nmt1-181 mutant at 36°C Saccharomyces cerevisiae
2.3.1.97 E293K site-directed mutagenesis, coexpression of wild-type with Asp451, functional complementation of enzyme deficient nmt1-181 mutant at 36°C Saccharomyces cerevisiae
2.3.1.97 additional information temperature sensitive mutant strain nmt1-181, exchange of Gly to Asp, 10fold increased Km for myristoyl-CoA at 36°C Saccharomyces cerevisiae
2.3.1.97 additional information disruption or deletion of nmt1-gene causes recessive lethality Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.97 myristoyl-CoA + glycylpeptide Saccharomyces cerevisiae
-
N-myristoylglycylpeptide + CoA
-
ir
2.3.1.97 myristoyl-CoA + protein Saccharomyces cerevisiae natural protein substrates are: catalytic subunit of cAMP-dependent protein kinase, p60src, phosphatases, e.g. calcineurin B, transmembrane signalling proteins, e.g. alpha-subunits of heterotrimeric G proteins, gag polyprotein precursors of several retroviruses, capsid proteins of some parvoviruses and picornaviruses ?
-
ir

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.97 no activity in Escherichia coli
-
-
-
2.3.1.97 Saccharomyces cerevisiae
-
gene nmt1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.97 myristoyl-CoA + glycylpeptide
-
Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
ir
2.3.1.97 myristoyl-CoA + glycylpeptide stereochemical requirements Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
ir
2.3.1.97 myristoyl-CoA + glycylpeptide specific for Gly at N-terminus Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
ir
2.3.1.97 myristoyl-CoA + glycylpeptide specific for myristoyl-CoA Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
ir
2.3.1.97 myristoyl-CoA + glycylpeptide p60src-derived peptides Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
ir
2.3.1.97 myristoyl-CoA + protein natural protein substrates are: catalytic subunit of cAMP-dependent protein kinase, p60src, phosphatases, e.g. calcineurin B, transmembrane signalling proteins, e.g. alpha-subunits of heterotrimeric G proteins, gag polyprotein precursors of several retroviruses, capsid proteins of some parvoviruses and picornaviruses Saccharomyces cerevisiae ?
-
ir

Synonyms

EC Number Synonyms Comment Organism
2.3.1.97 NMT
-
Saccharomyces cerevisiae