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Literature summary extracted from

  • Huth, W.; Dierich, C.; von Oeynhausen, V.; Seubert, W.
    Multiple mitochondrial forms of acetoacetyl-CoA thiolase in rat liver: possible regulatory role in ketogenesis (1974), Biochem. Biophys. Res. Commun., 56, 1069-1077.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.9 acetoacetyl-CoA isoenzyme A: above 0.015 mM, isoenzyme B: above 0.01 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.9 0.004
-
 acetoacetyl-CoA isoenzyme B, thiolysis Rattus norvegicus
2.3.1.9 0.006
-
 acetoacetyl-CoA isoenzyme A, thiolysis Rattus norvegicus
2.3.1.9 0.0062
-
 acetyl-CoA isoenzyme A Rattus norvegicus
2.3.1.9 0.022
-
 CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA Rattus norvegicus
-
 acetyl-CoA + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.9 Rattus norvegicus
-
 2 forms: A and B
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.9 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA
-
 Rattus norvegicus acetyl-CoA + acetyl-CoA
-
 ?
2.3.1.9 CoA + acetoacetyl-CoA
-
 Rattus norvegicus acetyl-CoA + acetyl-CoA
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.9 0.0014
-
 acetoacetyl-CoA isoenzyme A Rattus norvegicus