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Literature summary extracted from

  • Bloxham, D.P.; Chalkley, R.A.; Coghlin, S.J.; Salam, W.
    Synthesis of chloromethyl ketone derivatives of fatty acids. Their use as specific inhibitors of acetoacetyl-coenzyme A thiolase, cholesterol biosynthesis and fatty acid synthesis (1978), Biochem. J., 175, 999-1011.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.9 11-Chloro-10-oxoundecanoic acid acetyl-CoA or CoA protect Sus scrofa
2.3.1.9 11-chloro-10-oxoundecanoyl-CoA acetyl-CoA or CoA protect Sus scrofa
2.3.1.9 5-chloro-4-oxopentanoyl-CoA acetyl-CoA or CoA protect Sus scrofa
2.3.1.9 7-Chloro-6-oxoheptanoic acid acetyl-CoA or CoA protect Sus scrofa
2.3.1.9 7-chloro-6-oxoheptanoyl-CoA acetyl-CoA or CoA protect Sus scrofa
2.3.1.9 9-Chloro-8-oxononanoic acid acetyl-CoA or CoA protect Sus scrofa
2.3.1.9 9-chloro-8-oxononanoyl-CoA acetyl-CoA or CoA protect Sus scrofa
2.3.1.9 citraconic anhydride
-
 Sus scrofa
2.3.1.9 dec-3-ynoic acid irreversible inhibition Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA Sus scrofa
-
 acetyl-CoA + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.9 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.9 ammonium sulfate, acetone, acid treatment, CM-Sephadex, Sepharose 6B Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.9 heart
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.9 58.2
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA
-
 Sus scrofa acetyl-CoA + acetyl-CoA
-
 ?
2.3.1.9 CoA + acetoacetyl-CoA
-
 Sus scrofa acetyl-CoA + acetyl-CoA
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.9 0.0014
-
 9-chloro-8-oxononanoyl-CoA
-
 Sus scrofa
2.3.1.9 0.002
-
 7-chloro-6-oxoheptanoyl-CoA
-
 Sus scrofa
2.3.1.9 0.0025
-
 11-chloro-10-oxoundecanoyl-CoA
-
 Sus scrofa
2.3.1.9 0.015
-
 5-chloro-4-oxopentanoyl-CoA
-
 Sus scrofa
2.3.1.9 0.028
-
 11-Chloro-10-oxoundecanoic acid
-
 Sus scrofa
2.3.1.9 0.49
-
 9-Chloro-8-oxononanoic acid
-
 Sus scrofa
2.3.1.9 10
-
 dec-3-ynoic acid
-
 Sus scrofa
2.3.1.9 11.4
-
 7-Chloro-6-oxoheptanoic acid
-
 Sus scrofa