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Literature summary extracted from

  • Holland, P.C.; Clark, M.G.; Bloxham, D.P.
    Inactivation of pig heart thiolase by 3-butynoyl coenzyme A, 3-pentynoyl coenzyme A, and 4-bromocrotonyl coenzyme A (1973), Biochemistry, 12, 3309-3315.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.9 2-butynoyl-CoA 0.1 mM, 74% inactivation after 10 min Sus scrofa
2.3.1.9 3-butynoyl-CoA 0.01 mM, 95% inactivation after 10 min, acetoacetyl-CoA or 0.8 mM CoA protect Sus scrofa
2.3.1.9 3-pentynoyl-CoA 0.1 mM, complete inactivation after 10 min, acetoacetyl-CoA or 0.8 mM CoA protect Sus scrofa
2.3.1.9 3-Pentynoylpantetheine 1 mM, complete inactivation after 10 min Sus scrofa
2.3.1.9 4-bromocrotonyl-CoA 0.1 mM, complete inactivation after 10 min, acetoacetyl-CoA protects Sus scrofa
2.3.1.9 4-bromocrotonylpantetheine 1 mM, complete inactivation after 10 min Sus scrofa
2.3.1.9 Sodium borohydride inactivation in the presence of either acetoacetyl-CoA or acetyl-CoA Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA Sus scrofa
-
 acetyl-CoA + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.9 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.9 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA
-
 Sus scrofa acetyl-CoA + acetyl-CoA
-
 ?
2.3.1.9 CoA + acetoacetyl-CoA
-
 Sus scrofa acetyl-CoA + acetyl-CoA
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.9 0.013
-
 4-bromocrotonyl-CoA
-
 Sus scrofa
2.3.1.9 0.025
-
 3-pentynoyl-CoA
-
 Sus scrofa