BRENDA - Enzyme Database show

Reduced lecithin:retinol acyl transferase activity in cultured squamous cell carcinoma lines results in increased substrate-driven retinoic acid synthesis

Jurukovski, V.; Simon, M.; Biochim. Biophys. Acta 1436, 479-490 (1999)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.76
additional information
not enhanced by retinoic acids
Homo sapiens
Application
EC Number
Application
Commentary
Organism
2.3.1.76
medicine
keratinocyte growth and differentiation
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.76
microsome
membrane fraction
Homo sapiens
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.76
acyl-CoA + retinol
Homo sapiens
-
CoA + retinyl ester
-
Homo sapiens
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.76
Homo sapiens
-
cell cultures
-
Purification (Commentary)
EC Number
Commentary
Organism
2.3.1.76
partial purification by differential centrifugation
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.76
carcinoma cell
squamous SCC12b and SCC13b lines are common type of skin cancer that has reduced capacity to esterify retinol relative to normal keratinocytes
Homo sapiens
-
2.3.1.76
keratinocyte
D033 line
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.3.1.76
additional information
-
activity determined from microsomes
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.76
acyl-CoA + retinol
-
487496
Homo sapiens
CoA + retinyl ester
-
487496
Homo sapiens
?
2.3.1.76
oleoyl-CoA + retinol
-
487496
Homo sapiens
CoA + retinyloleolate
-
487496
Homo sapiens
?
2.3.1.76
palmitoyl-CoA + retinol
-
487496
Homo sapiens
CoA + retinylpalmitate
-
487496
Homo sapiens
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.76
additional information
not enhanced by retinoic acids
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
2.3.1.76
medicine
keratinocyte growth and differentiation
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.76
microsome
membrane fraction
Homo sapiens
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.76
acyl-CoA + retinol
Homo sapiens
-
CoA + retinyl ester
-
Homo sapiens
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.76
partial purification by differential centrifugation
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.76
carcinoma cell
squamous SCC12b and SCC13b lines are common type of skin cancer that has reduced capacity to esterify retinol relative to normal keratinocytes
Homo sapiens
-
2.3.1.76
keratinocyte
D033 line
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.3.1.76
additional information
-
activity determined from microsomes
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.76
acyl-CoA + retinol
-
487496
Homo sapiens
CoA + retinyl ester
-
487496
Homo sapiens
?
2.3.1.76
oleoyl-CoA + retinol
-
487496
Homo sapiens
CoA + retinyloleolate
-
487496
Homo sapiens
?
2.3.1.76
palmitoyl-CoA + retinol
-
487496
Homo sapiens
CoA + retinylpalmitate
-
487496
Homo sapiens
?