BRENDA - Enzyme Database show

2,3,7,8-Tetrachlorodibenzo-p-dioxin affects retinol esterification in rat hepatic stellate cells and kidney

Nilsson, C.B.; Hanber, A.; Trossvik, C.; Haekansson, H.; Environ. Toxicol. Pharmacol. 2, 17-23 (1996)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.76
2,3,7,8-tetrachlorodibenzo-p-dioxin
decreased activity
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.76
microsome
membrane fraction
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.76
acyl-CoA + retinol
Rattus norvegicus
-
CoA + retinyl ester
-
Rattus norvegicus
?
2.3.1.76
acyl-CoA + retinol
Rattus norvegicus Sprague-Dawley
-
CoA + retinyl ester
-
Rattus norvegicus Sprague-Dawley
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.76
Rattus norvegicus
-
Sprague-Dawley
-
2.3.1.76
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-
Purification (Commentary)
EC Number
Commentary
Organism
2.3.1.76
partial purification by differential centrifugation
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.76
kidney
-
Rattus norvegicus
-
2.3.1.76
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.3.1.76
additional information
-
activity determined from microsomes
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.76
acyl-CoA + retinol
-
487494
Rattus norvegicus
CoA + retinyl ester
-
487494
Rattus norvegicus
?
2.3.1.76
acyl-CoA + retinol
-
487494
Rattus norvegicus Sprague-Dawley
CoA + retinyl ester
-
487494
Rattus norvegicus Sprague-Dawley
?
2.3.1.76
palmitoyl-CoA + retinol
-
487494
Rattus norvegicus
CoA + retinylpalmitate
-
487494
Rattus norvegicus
?
2.3.1.76
palmitoyl-CoA + retinol
-
487494
Rattus norvegicus Sprague-Dawley
CoA + retinylpalmitate
-
487494
Rattus norvegicus Sprague-Dawley
?
pH Stability
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
2.3.1.76
7.2
-
phosphate buffer
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.76
2,3,7,8-tetrachlorodibenzo-p-dioxin
decreased activity
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.76
microsome
membrane fraction
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.76
acyl-CoA + retinol
Rattus norvegicus
-
CoA + retinyl ester
-
Rattus norvegicus
?
2.3.1.76
acyl-CoA + retinol
Rattus norvegicus Sprague-Dawley
-
CoA + retinyl ester
-
Rattus norvegicus Sprague-Dawley
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.76
partial purification by differential centrifugation
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.76
kidney
-
Rattus norvegicus
-
2.3.1.76
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.3.1.76
additional information
-
activity determined from microsomes
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.76
acyl-CoA + retinol
-
487494
Rattus norvegicus
CoA + retinyl ester
-
487494
Rattus norvegicus
?
2.3.1.76
acyl-CoA + retinol
-
487494
Rattus norvegicus Sprague-Dawley
CoA + retinyl ester
-
487494
Rattus norvegicus Sprague-Dawley
?
2.3.1.76
palmitoyl-CoA + retinol
-
487494
Rattus norvegicus
CoA + retinylpalmitate
-
487494
Rattus norvegicus
?
2.3.1.76
palmitoyl-CoA + retinol
-
487494
Rattus norvegicus Sprague-Dawley
CoA + retinylpalmitate
-
487494
Rattus norvegicus Sprague-Dawley
?
pH Stability (protein specific)
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
2.3.1.76
7.2
-
phosphate buffer
Rattus norvegicus