Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lee, T.C.
    Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes (1985), J. Biol. Chem., 260, 10952-10955.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 palmitoyllyso-glycero-3-phosphocholine competitive inhibitor for alkyl-sn-glycero-3-phosphocholine Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.67 0.02
-
 hexanoyl-CoA
-
 Rattus norvegicus
2.3.1.67 0.046
-
 butyryl-CoA
-
 Rattus norvegicus
2.3.1.67 0.128
-
 propionyl-CoA
-
 Rattus norvegicus
2.3.1.67 0.173
-
 acetyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.67 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine rate reduced to 50% Rattus norvegicus CoA + 2-acetyl-1-palmitoyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine least enzyme activity Rattus norvegicus CoA + 2-acetyl-alkyl-glycero-3-phosphoethanolamine
-
 ?
2.3.1.67 acetyl-CoA + alkyl-lyso-monomethylethanamine
-
 Rattus norvegicus ?
-
 ?
2.3.1.67 acetyl-CoA + alkyl-lyso-N',N'-dimethylethanamine
-
 Rattus norvegicus ?
-
 ?
2.3.1.67 acetyl-CoA + alkyl-sn-glycero-3-phosphocholine the higher the degree of methylation of the nitrogen base, the lower the enzyme activity Rattus norvegicus CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + alkyl-sn-glycero-3-phosphocholine the longer the acyl-CoA length, the smaller the values of apparent Km and Vmax Rattus norvegicus CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + alkyl-sn-glycero-3-phosphocholine alkyl-lyso-sn-glycero-3-phosphocholine is preferred to its saturated counterpart as substrate Rattus norvegicus CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
-
 Rattus norvegicus CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 butyryl-CoA + 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
-
 Rattus norvegicus 2-butyryl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 hexanoyl-CoA + 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
-
 Rattus norvegicus 2-hexanoyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 propionyl-CoA + alkyl-lyso-glycero-phosphocholine
-
 Rattus norvegicus CoA + 2-propionyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?