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Literature summary extracted from

  • Chevereau, M.; Daniels, P.J.L.; Davies, J.; LeGoffic, F.
    Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2-amino group of aminoglycoside antibiotics (1974), Biochemistry, 13, 598-603.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.3.1.59 activity in crude enzyme preparation is stable to repeated freezing and thawing Providencia sp.

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.59 Providencia sp.
-
 clinical isolate
-
2.3.1.59 Providencia sp. 164
-
 clinical isolate
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.59 acetyl-CoA + butirosin acetylated at 30% the rate of gentamicin C1 Providencia sp. CoA + ?
-
 ?
2.3.1.59 acetyl-CoA + dideoxykanamycin acetylated at 92% the rate of gentamicin C1 Providencia sp. CoA + N2'-diacetyldideoxykanamycin
-
 ?
2.3.1.59 acetyl-CoA + gentamicin B 7% of the activity with gentamicin C1 Providencia sp. CoA + N2'-acetylgentamycin
-
 ?
2.3.1.59 acetyl-CoA + gentamicin C1 best substrate Providencia sp. CoA + N2'-acetylgentamicin C1
-
 ?
2.3.1.59 acetyl-CoA + gentamicin C1 best substrate Providencia sp. 164 CoA + N2'-acetylgentamicin C1
-
 ?
2.3.1.59 acetyl-CoA + gentamicin C1a acetylated at 86% the rate of gentamicin C1 Providencia sp. CoA + N2'-acetylgentamicin C1a
-
 ?
2.3.1.59 acetyl-CoA + gentamicin C1a acetylated at 86% the rate of gentamicin C1 Providencia sp. 164 CoA + N2'-acetylgentamicin C1a
-
 ?
2.3.1.59 acetyl-CoA + kanamycin B acetylated at 14% the rate of gentamicin C1 Providencia sp. CoA + N2-acetylkanamycin B
-
 ?
2.3.1.59 acetyl-CoA + kanamycin C acetylated at 40% the rate of gentamicin C1 Providencia sp. CoA + N2'-acetylkanamycin C
-
 ?
2.3.1.59 acetyl-CoA + neomycin B acetylated at 10% the rate of gentamicin C1 Providencia sp. CoA + N2'-acetylneomycin B
-
 ?
2.3.1.59 acetyl-CoA + ribostamycin acetylated at 15% the rate of gentamicin C1 Providencia sp. CoA + N2'-acetylribostamycin
-
 ?
2.3.1.59 acetyl-CoA + sisomicin acetylated at 71% the rate of gentamicin C1 Providencia sp. CoA + N3'-acetylsisomicin
-
 ?
2.3.1.59 acetyl-CoA + sisomicin acetylated at 71% the rate of gentamicin C1 Providencia sp. 164 CoA + N3'-acetylsisomicin
-
 ?
2.3.1.59 acetyl-CoA + tobramycin acetylated at 58% the rate of gentamicin C1 Providencia sp. CoA + N2'-acetyltobramycin
-
 ?
2.3.1.59 acetyl-CoA + tobramycin acetylated at 58% the rate of gentamicin C1 Providencia sp. 164 CoA + N2'-acetyltobramycin
-
 ?
2.3.1.59 acetyl-CoA of soluble fragments of peptidoglycan + tobramycin acetylated at 58% the rate of gentamicin C1 Providencia sp. ?
-
 ?
2.3.1.59 additional information no substrates are kanamycin A and 1-hydroxyaminobutyric acid kanamycin A-derivative BB-K 8 Providencia sp. ?
-
 ?
2.3.1.59 additional information no substrates are kanamycin A and 1-hydroxyaminobutyric acid kanamycin A-derivative BB-K 8 Providencia sp. 164 ?
-
 ?
2.3.1.59 N-acetyl-D-glucosamine + tobramycin acetylated at 58% the rate of gentamicin C1 Providencia sp. D-glucosamine + N2'-acetyltobramycin
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.59 6
-
 kanamycin C Providencia sp.
2.3.1.59 6.6
-
 gentamicin C Providencia sp.

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.59 5.7 6.5 about half-maximal activity at pH 5.7 and 6.5, kanamycin C Providencia sp.
2.3.1.59 6.4 7.6 about half-maximal activity at pH 6.4 and 7.6, gentamicin C Providencia sp.