BRENDA - Enzyme Database

Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria

Benveniste, R.; Davies, J.; Proc. Natl. Acad. Sci. USA 70, 2276-2280 (1973)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.3.1.59
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces kanamyceticus
2.3.1.59
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces spectabilis
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.59
cytoplasm
-
Streptomyces spectabilis
5737
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
2.3.1.59
additional information
Streptomyces spectabilis
modification of antibiotics
?
-
-
?
2.3.1.82
additional information
Streptomyces kanamyceticus
involved in resistance to antibiotics
?
-
-
-
Organism
EC Number
Organism
UniProt
Commentary
Textmining
2.3.1.59
Streptomyces kanamyceticus
-
-
-
2.3.1.59
Streptomyces spectabilis
-
-
-
2.3.1.82
Streptomyces kanamyceticus
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2.3.1.59
acetyl-CoA + gentamicin C1
-
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1
-
-
-
?
2.3.1.59
acetyl-CoA + gentamicin C1a
-
487272
Streptomyces kanamyceticus
CoA + N2'-acetylgentamicin C1a
-
-
-
?
2.3.1.59
acetyl-CoA + gentamicin C1a
acetylates 2'-amino group of hexose moiety
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1a
-
487272
Streptomyces spectabilis
?
2.3.1.59
acetyl-CoA + kanamycin B
-
487272
Streptomyces spectabilis
CoA + N2-acetylkanamycin B
-
-
-
?
2.3.1.59
acetyl-CoA + kanamycin C
-
487272
Streptomyces spectabilis
CoA + N2'-acetylkanamycin C
-
-
-
?
2.3.1.59
acetyl-CoA + paromomycin
-
487272
Streptomyces spectabilis
CoA + N2'-acetylparomomycin
-
-
-
?
2.3.1.59
additional information
-
487272
Streptomyces spectabilis
?
-
-
-
-
2.3.1.59
additional information
modification of antibiotics
487272
Streptomyces spectabilis
?
-
-
-
?
2.3.1.82
acetyl-CoA + gentamicin C1a
-
487272
Streptomyces kanamyceticus
CoA + N6'-acetylgentamicin C1a
-
487272
Streptomyces kanamyceticus
?
2.3.1.82
additional information
involved in resistance to antibiotics
487272
Streptomyces kanamyceticus
?
-
-
-
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.3.1.59
5.3
-
-
Streptomyces spectabilis
2.3.1.82
7.4
-
-
Streptomyces kanamyceticus
Application (protein specific)
EC Number
Application
Commentary
Organism
2.3.1.59
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces kanamyceticus
2.3.1.59
analysis
rapid analysis of antibiotic concentration in serum
Streptomyces spectabilis
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.59
cytoplasm
-
Streptomyces spectabilis
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
2.3.1.59
additional information
Streptomyces spectabilis
modification of antibiotics
?
-
-
?
2.3.1.82
additional information
Streptomyces kanamyceticus
involved in resistance to antibiotics
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2.3.1.59
acetyl-CoA + gentamicin C1
-
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1
-
-
-
?
2.3.1.59
acetyl-CoA + gentamicin C1a
-
487272
Streptomyces kanamyceticus
CoA + N2'-acetylgentamicin C1a
-
-
-
?
2.3.1.59
acetyl-CoA + gentamicin C1a
acetylates 2'-amino group of hexose moiety
487272
Streptomyces spectabilis
CoA + N2'-acetylgentamicin C1a
-
487272
Streptomyces spectabilis
?
2.3.1.59
acetyl-CoA + kanamycin B
-
487272
Streptomyces spectabilis
CoA + N2-acetylkanamycin B
-
-
-
?
2.3.1.59
acetyl-CoA + kanamycin C
-
487272
Streptomyces spectabilis
CoA + N2'-acetylkanamycin C
-
-
-
?
2.3.1.59
acetyl-CoA + paromomycin
-
487272
Streptomyces spectabilis
CoA + N2'-acetylparomomycin
-
-
-
?
2.3.1.59
additional information
-
487272
Streptomyces spectabilis
?
-
-
-
-
2.3.1.59
additional information
modification of antibiotics
487272
Streptomyces spectabilis
?
-
-
-
?
2.3.1.82
acetyl-CoA + gentamicin C1a
-
487272
Streptomyces kanamyceticus
CoA + N6'-acetylgentamicin C1a
-
487272
Streptomyces kanamyceticus
?
2.3.1.82
additional information
involved in resistance to antibiotics
487272
Streptomyces kanamyceticus
?
-
-
-
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.3.1.59
5.3
-
-
Streptomyces spectabilis
2.3.1.82
7.4
-
-
Streptomyces kanamyceticus