Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria

Benveniste, R.; Davies, J.; Proc. Natl. Acad. Sci. USA 70, 2276-2280 (1973)

Data extracted from this reference:

EC Number

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

2.3.1.59

additional information

Streptomyces spectabilis

modification of antibiotics

?

-

-

?

2.3.1.82

additional information

Streptomyces kanamyceticus

involved in resistance to antibiotics

?

-

-

-

EC Number

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

2.3.1.59

acetyl-CoA + gentamicin C1

-

487272

Streptomyces spectabilis

CoA + N2'-acetylgentamicin C1

-

-

-

?

2.3.1.59

acetyl-CoA + gentamicin C1a

-

487272

Streptomyces kanamyceticus

CoA + N2'-acetylgentamicin C1a

-

-

-

?

2.3.1.59

acetyl-CoA + gentamicin C1a

acetylates 2'-amino group of hexose moiety

487272

Streptomyces spectabilis

CoA + N2'-acetylgentamicin C1a

-

487272

Streptomyces spectabilis

?

2.3.1.59

acetyl-CoA + kanamycin B

-

487272

Streptomyces spectabilis

CoA + N2-acetylkanamycin B

-

-

-

?

2.3.1.59

acetyl-CoA + kanamycin C

-

487272

Streptomyces spectabilis

CoA + N2'-acetylkanamycin C

-

-

-

?

2.3.1.59

acetyl-CoA + paromomycin

-

487272

Streptomyces spectabilis

CoA + N2'-acetylparomomycin

-

-

-

?

2.3.1.59

additional information

-

487272

Streptomyces spectabilis

?

-

-

-

-

2.3.1.59

additional information

modification of antibiotics

487272

Streptomyces spectabilis

?

-

-

-

?

2.3.1.82

acetyl-CoA + gentamicin C1a

-

487272

Streptomyces kanamyceticus

CoA + N6'-acetylgentamicin C1a

-

487272

Streptomyces kanamyceticus

?

2.3.1.82

additional information

involved in resistance to antibiotics

487272

Streptomyces kanamyceticus

?

-

-

-

-

EC Number

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

2.3.1.59

additional information

Streptomyces spectabilis

modification of antibiotics

?

-

-

?

2.3.1.82

additional information

Streptomyces kanamyceticus

involved in resistance to antibiotics

?

-

-

-

EC Number

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

2.3.1.59

acetyl-CoA + gentamicin C1

-

487272

Streptomyces spectabilis

CoA + N2'-acetylgentamicin C1

-

-

-

?

2.3.1.59

acetyl-CoA + gentamicin C1a

-

487272

Streptomyces kanamyceticus

CoA + N2'-acetylgentamicin C1a

-

-

-

?

2.3.1.59

acetyl-CoA + gentamicin C1a

acetylates 2'-amino group of hexose moiety

487272

Streptomyces spectabilis

CoA + N2'-acetylgentamicin C1a

-

487272

Streptomyces spectabilis

?

2.3.1.59

acetyl-CoA + kanamycin B

-

487272

Streptomyces spectabilis

CoA + N2-acetylkanamycin B

-

-

-

?

2.3.1.59

acetyl-CoA + kanamycin C

-

487272

Streptomyces spectabilis

CoA + N2'-acetylkanamycin C

-

-

-

?

2.3.1.59

acetyl-CoA + paromomycin

-

487272

Streptomyces spectabilis

CoA + N2'-acetylparomomycin

-

-

-

?

2.3.1.59

additional information

-

487272

Streptomyces spectabilis

?

-

-

-

-

2.3.1.59

additional information

modification of antibiotics

487272

Streptomyces spectabilis

?

-

-

-

?

2.3.1.82

acetyl-CoA + gentamicin C1a

-

487272

Streptomyces kanamyceticus

CoA + N6'-acetylgentamicin C1a

-

487272

Streptomyces kanamyceticus

?

2.3.1.82

additional information

involved in resistance to antibiotics

487272

Streptomyces kanamyceticus

?

-

-

-

-