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Literature summary extracted from

  • Bartsch, H.; Dworkin, C.; Miller, E.C.; Miller, J.A.
    Formation of electrophilic N-acetoxyarylamines in cytosols from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl (1973), Biochim. Biophys. Acta, 304, 42-55.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.56 reduced pyridine nucleotides mammary gland Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.56 iodoacetamide
-
 Rattus norvegicus
2.3.1.56 N-ethylmaleimide
-
 Rattus norvegicus
2.3.1.56 NaF weak Rattus norvegicus
2.3.1.56 PCMB
-
 Rattus norvegicus
2.3.1.56 puromycin weak Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.56 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.56 N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl Rattus norvegicus transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.56 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.56 kidney
-
 Rattus norvegicus
-
2.3.1.56 liver
-
 Rattus norvegicus
-
2.3.1.56 mammary gland
-
 Rattus norvegicus
-
2.3.1.56 additional information no activity in rat ear duct sebaceous gland, lung, dog urinary bladder mucosa Rattus norvegicus
-
2.3.1.56 muscle low activity Rattus norvegicus
-
2.3.1.56 small intestine mucosa
-
 Rattus norvegicus
-
2.3.1.56 spleen low activity Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.3.1.56 0-4°C, about 30% loss of activity after 6 h Rattus norvegicus
2.3.1.56 0-4°C, inactivation after 18 h Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.56 N-hydroxy-2-acetylaminofluorene + N-hydroxy-4-aminobiphenyl i.e. N-hydroxy-N2-fluorenylacetamide, not mammary gland enzyme Rattus norvegicus N-hydroxy-2-aminofluorene + N-acetoxy-4-aminobiphenyl
-
 ?
2.3.1.56 N-hydroxy-4-acetylaminobiphenyl + 4-aminoazobenzene
-
 Rattus norvegicus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminoazobenzene
-
 ?
2.3.1.56 N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl Rattus norvegicus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
 ?
2.3.1.56 N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl transfers the N-acetyl group of some aromatic acethydroxamic acids to the O-position of some aromatic hydroxylamines Rattus norvegicus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.56 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.56 6.8
-
 liver Rattus norvegicus
2.3.1.56 7.5
-
 mammary gland Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.56 6.8 8.2 about 80% of maximal activity at pH 6.8 and pH 8.2 Rattus norvegicus