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Literature summary extracted from

  • Hein, D.W.
    Acetylator genotype and arylamine-induced carcinogenesis (1988), Biochim. Biophys. Acta, 948, 37-66.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.5 cytosol
-
Salmonella enterica subsp. enterica serovar Typhimurium 5829
-
2.3.1.5 cytosol
-
Mus musculus 5829
-
2.3.1.5 cytosol
-
Homo sapiens 5829
-
2.3.1.5 cytosol
-
Oryctolagus cuniculus 5829
-
2.3.1.5 cytosol
-
Mesocricetus auratus 5829
-
2.3.1.56 cytosol
-
Rattus norvegicus 5829
-
2.3.1.56 cytosol
-
Oryctolagus cuniculus 5829
-
2.3.1.56 cytosol
-
Mesocricetus auratus 5829
-
2.3.1.118 cytosol
-
Salmonella enterica subsp. enterica serovar Typhimurium 5829
-
2.3.1.118 cytosol
-
Mus musculus 5829
-
2.3.1.118 cytosol
-
Homo sapiens 5829
-
2.3.1.118 cytosol
-
Mesocricetus auratus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.118 33000
-
gel filtration Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Salmonella enterica subsp. enterica serovar Typhimurium involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Mus musculus involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Homo sapiens involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Mesocricetus auratus involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Salmonella enterica subsp. enterica serovar Typhimurium the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Mus musculus the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Homo sapiens the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Mesocricetus auratus the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Mus musculus C57/BL6J involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine Mus musculus C57/BL6J the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates CoA + an N-acetoxyarylamine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens
-
-
-
2.3.1.5 Mesocricetus auratus
-
-
-
2.3.1.5 Mus musculus
-
-
-
2.3.1.5 no activity in Canis familiaris
-
-
-
2.3.1.5 Oryctolagus cuniculus
-
-
-
2.3.1.5 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
2.3.1.56 Mesocricetus auratus
-
-
-
2.3.1.56 no activity in Cavia porcellus
-
-
-
2.3.1.56 no activity in Mus musculus
-
-
-
2.3.1.56 Oryctolagus cuniculus
-
-
-
2.3.1.56 Rattus norvegicus
-
-
-
2.3.1.118 Homo sapiens
-
-
-
2.3.1.118 Mesocricetus auratus
-
-
-
2.3.1.118 Mus musculus
-
-
-
2.3.1.118 Mus musculus C57/BL6J
-
-
-
2.3.1.118 Oryctolagus cuniculus
-
-
-
2.3.1.118 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.118
-
Mus musculus
2.3.1.118 monomeric isozyme Mesocricetus auratus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Mus musculus
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Homo sapiens
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Oryctolagus cuniculus
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 bladder
-
Mesocricetus auratus
-
2.3.1.5 intestine
-
Homo sapiens
-
2.3.1.5 intestine
-
Oryctolagus cuniculus
-
2.3.1.5 intestine
-
Mesocricetus auratus
-
2.3.1.5 liver
-
Mus musculus
-
2.3.1.5 liver
-
Homo sapiens
-
2.3.1.5 liver
-
Oryctolagus cuniculus
-
2.3.1.5 liver
-
Mesocricetus auratus
-
2.3.1.5 lung
-
Mesocricetus auratus
-
2.3.1.5 additional information
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
2.3.1.5 additional information distribution in mammalian tissues Mus musculus
-
2.3.1.5 additional information distribution in mammalian tissues Homo sapiens
-
2.3.1.5 additional information distribution in mammalian tissues Oryctolagus cuniculus
-
2.3.1.5 additional information distribution in mammalian tissues Mesocricetus auratus
-
2.3.1.56 kidney
-
Rattus norvegicus
-
2.3.1.56 liver
-
Rattus norvegicus
-
2.3.1.56 liver
-
Oryctolagus cuniculus
-
2.3.1.56 liver
-
Mesocricetus auratus
-
2.3.1.56 additional information
-
Mesocricetus auratus
-
2.3.1.56 additional information no activity in rat ear duct sebaceous gland, lung, dog urinary bladder mucosa Rattus norvegicus
-
2.3.1.56 additional information rabbit bladder Oryctolagus cuniculus
-
2.3.1.56 small intestine mucosa
-
Rattus norvegicus
-
2.3.1.118 bladder low level of activity Mus musculus
-
2.3.1.118 bladder low level of activity Homo sapiens
-
2.3.1.118 bladder low level of activity Mesocricetus auratus
-
2.3.1.118 colon different phenotypes Homo sapiens
-
2.3.1.118 intestine
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
2.3.1.118 intestine
-
Mus musculus
-
2.3.1.118 intestine
-
Mesocricetus auratus
-
2.3.1.118 kidney
-
Mus musculus
-
2.3.1.118 kidney
-
Homo sapiens
-
2.3.1.118 kidney
-
Mesocricetus auratus
-
2.3.1.118 liver
-
Mus musculus
-
2.3.1.118 liver
-
Oryctolagus cuniculus
-
2.3.1.118 liver high polymorphism, two isozymes with different chromatographic properties and kinetic constants Mesocricetus auratus
-
2.3.1.118 liver different phenotypes Homo sapiens
-
2.3.1.118 lung
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
2.3.1.118 lung
-
Mus musculus
-
2.3.1.118 lung
-
Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.5 additional information
-
-
Mus musculus
2.3.1.5 additional information
-
-
Homo sapiens
2.3.1.5 additional information
-
-
Oryctolagus cuniculus
2.3.1.5 additional information
-
-
Mesocricetus auratus
2.3.1.118 additional information
-
specific activities in different tissues for three hamster phenotypes Mesocricetus auratus
2.3.1.118 additional information
-
activity in different tissues might be related to carcinogenesis Homo sapiens
2.3.1.118 0.00196
-
kidney Mesocricetus auratus
2.3.1.118 0.0024
-
intestine Mesocricetus auratus
2.3.1.118 0.0042
-
lung Mesocricetus auratus
2.3.1.118 0.0058
-
liver Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
Mus musculus CoA + 4-acetylaminobenzoic acid
-
?
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
Homo sapiens CoA + 4-acetylaminobenzoic acid
-
?
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
Oryctolagus cuniculus CoA + 4-acetylaminobenzoic acid
-
?
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
Mesocricetus auratus CoA + 4-acetylaminobenzoic acid
-
?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid
-
Mus musculus CoA + 4-acetylamino-2-hydroxybenzoate
-
?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid
-
Homo sapiens CoA + 4-acetylamino-2-hydroxybenzoate
-
?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid
-
Oryctolagus cuniculus CoA + 4-acetylamino-2-hydroxybenzoate
-
?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid
-
Mesocricetus auratus CoA + 4-acetylamino-2-hydroxybenzoate
-
?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid
-
Mus musculus C57/BL6J CoA + 4-acetylamino-2-hydroxybenzoate
-
?
2.3.1.5 additional information
-
Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?
2.3.1.5 additional information the reaction proceeds via a covalent acetyl-enzyme intermediate Mus musculus ?
-
?
2.3.1.5 additional information the reaction proceeds via a covalent acetyl-enzyme intermediate Homo sapiens ?
-
?
2.3.1.5 additional information the reaction proceeds via a covalent acetyl-enzyme intermediate Oryctolagus cuniculus ?
-
?
2.3.1.5 additional information the reaction proceeds via a covalent acetyl-enzyme intermediate Mesocricetus auratus ?
-
?
2.3.1.5 additional information the reaction proceeds via a covalent acetyl-enzyme intermediate Mus musculus C57/BL6J ?
-
?
2.3.1.56 N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl Rattus norvegicus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
?
2.3.1.56 N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl Oryctolagus cuniculus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
?
2.3.1.56 N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl S-acetyl-CoA cannot replace N-hydroxy-4-acetylaminobiphenyl Mesocricetus auratus N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl
-
?
2.3.1.118 acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Salmonella enterica subsp. enterica serovar Typhimurium CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?
2.3.1.118 acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Mus musculus CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?
2.3.1.118 acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Homo sapiens CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?
2.3.1.118 acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Mesocricetus auratus CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?
2.3.1.118 acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Mus musculus C57/BL6J CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species Salmonella enterica subsp. enterica serovar Typhimurium CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species Mus musculus CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species Homo sapiens CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species Mesocricetus auratus CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates Salmonella enterica subsp. enterica serovar Typhimurium CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates Mus musculus CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates Homo sapiens CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates Mesocricetus auratus CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species Mus musculus C57/BL6J CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + an N-hydroxyarylamine the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates Mus musculus C57/BL6J CoA + an N-acetoxyarylamine
-
?
2.3.1.118 acetyl-CoA + N-hydroxy-3,2'-dimethyl-4-aminobiphenyl
-
Mesocricetus auratus CoA + N-acetoxy-3,2'-dimethyl-4-aminobiphenyl
-
?
2.3.1.118 acetyl-CoA + N-hydroxy-4-aminobiphenyl
-
Homo sapiens CoA + N-acetoxy-4-aminobiphenyl
-
?
2.3.1.118 acetyl-CoA + N-hydroxy-4-aminobiphenyl
-
Mesocricetus auratus CoA + N-acetoxy-4-aminobiphenyl
-
?